Loratadine + Pseudoephedrine

Indications

Allergic Rhinitis Fever Urticaria

The Loratadine + Pseudoephedrine tablet is meant for use when you want both the antihistamine action of Loratadine and the nasal decongestant action of Pseudoephedrine. It is indicated for relief of these symptoms caused by hay fever or other upper respiratory allergies: nasal congestion, runny nose, sneezing, itchy, watery eyes, itching of the nose or throat, swelling of nasal passages, and sinus congestion and pressure.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Loratadine is a long acting tricyclic anti-histamine that blocks histamine H1-receptors. It has anti-allergic properties and does not cause sedation. Its action is selective for the peripheral H1-receptors, and it has no central sedative or anti-cholinergic effect.

Pseudoephedrine is an orally active sympathomimetic amine. It acts as a decongestant on the nasal mucosa and is recognized as an effective agent for relieving nasal congestion due to allergic rhinitis. It has both nasal and bronchial decongestant activity. Pseudoephedrine is an α- and β-adrenergic receptor agonist. By directly stimulating the α-adrenergic receptors of the respiratory mucosa, it causes vasoconstriction. It also directly stimulates β-adrenergic receptors, which causes bronchial relaxation and an increase in heart rate and contractility.

Pregnancy & Breastfeeding

Loratadine + Pseudoephedrine falls under pregnancy category B, and no evidence of risk in humans has been reported. It isn't known whether this combination product passes into human milk. But loratadine and pseudoephedrine both pass into breast milk when given alone, so the combination should not be given to breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and children over 12 years can take the 5/120 tablet as one tablet twice daily, every 12 hours. The 10/240 tablet is one tablet once daily, and it should be taken in the morning rather than at night. People with renal insufficiency (GFR<30 ml/min) should start on a lower dose, which is one 5/120 tablet per day or one 10/240 tablet every alternate day. This is because their bodies clear Loratadine and Pseudoephedrine more slowly. The 10/240 tablet should not be used by anyone with a history of difficulty in swallowing tablets, known narrowing of the upper gastrointestinal tract, or abnormal esophageal peristalsis. Paediatric use: Safety and effectiveness in children below the age of 12 years have not been established. Use in patients approximately 60 years of age and older: The safety and efficacy of this tablet in patients older than 60 years have not been investigated in placebo-controlled clinical trials. Elderly people are more likely to have adverse reactions to sympathomimetic amines.

Suggest a correction

Loratadine + Pseudoephedrine

Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions