Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Istradefylline

Antiparkinson drugs Prescription
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Indications

Parkinson's Disease

Istradefylline tablet is an adenosine receptor antagonist. Doctors use it as an add-on treatment to levodopa/carbidopa in adult patients with Parkinson's disease who have "off" episodes.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Istradefylline is a selective adenosine A2A receptor inhibitor. These receptors sit in the basal ganglia, the part of the brain that degenerates in Parkinson's disease and also plays a large part in controlling movement. A2A receptors are also found on GABAergic medium spiny neurons in the indirect striato-pallidal pathway, so the GABAergic action of this pathway is reduced. Istradefylline binds A2A receptors with 56 times the affinity it has for A1 receptors.

Pregnancy & Breastfeeding

Istradefylline is not recommended during pregnancy, because studies suggest it may cause fetal harm. For breastfeeding, there are no data on whether Istradefylline passes into human milk. Its effects on the breastfed infant and on milk production are also unknown. So a nursing woman should take care when it is given to her.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual dose of Istradefylline is 20 mg taken by mouth once a day. The doctor can raise it to a maximum of 40 mg once daily, depending on the patient's need and how well they tolerate it. For patients who smoke 20 or more cigarettes a day (or use the equivalent amount of another tobacco product), the recommended dose is 40 mg once daily. Patients with hepatic impairment: if the impairment is moderate, the maximum recommended dose is 20 mg once daily. In severe hepatic impairment, Istradefylline should be avoided. Use in children: safety and effectiveness of Istradefylline in pediatric patients have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.