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Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Aric is indicated for:
Pharmacology
Istradefylline is a selective adenosine A2A receptor inhibitor. These receptors sit in the basal ganglia, the part of the brain that degenerates in Parkinson's disease and also plays a large part in controlling movement. A2A receptors are also found on GABAergic medium spiny neurons in the indirect striato-pallidal pathway, so the GABAergic action of this pathway is reduced. Istradefylline binds A2A receptors with 56 times the affinity it has for A1 receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Istradefylline is 20 mg taken by mouth once a day. The doctor can raise it to a maximum of 40 mg once daily, depending on the patient's need and how well they tolerate it. For patients who smoke 20 or more cigarettes a day (or use the equivalent amount of another tobacco product), the recommended dose is 40 mg once daily.
Patients with hepatic impairment: if the impairment is moderate, the maximum recommended dose is 20 mg once daily. In severe hepatic impairment, Istradefylline should be avoided.
Use in children: safety and effectiveness of Istradefylline in pediatric patients have not been established.
Side Effects
Istradefylline most commonly causes dyskinesia, dizziness, constipation, nausea, hallucination and insomnia.
Cautions & Contraindications
Warnings & Precautions
Patients taking Istradefylline should be watched for dyskinesia, and for any worsening of dyskinesia they already have. If hallucinations, psychotic behaviour, impulse control problems or compulsive behaviours appear, the doctor should think about lowering the dose or stopping Istradefylline.
Contraindications
Don't give Istradefylline to anyone who is known to be hypersensitive to any component of the medicine. It is also contraindicated in people with severe hepatic impairment.
Pregnancy & Breastfeeding
Istradefylline is not recommended during pregnancy, because studies suggest it may cause fetal harm. For breastfeeding, there are no data on whether Istradefylline passes into human milk. Its effects on the breastfed infant and on milk production are also unknown. So a nursing woman should take care when it is given to her.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Doctors have very little clinical experience of overdose with Istradefylline in people. If an overdose happens, Istradefylline should be stopped and supportive treatment given as the doctor sees fit.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Istradefylline below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Aric 20 mg
What is Aric 20 mg Tablet?
Aric 20 mg Tablet is a medicine that contains Istradefylline. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Antiparkinson drugs group of medicines.
What is Aric used for?
Aric is used for: Parkinson's Disease.
What are the side effects of Aric?
Istradefylline most commonly causes dyskinesia, dizziness, constipation, nausea, hallucination and insomnia.
Can I take Aric during pregnancy or while breastfeeding?
Istradefylline is not recommended during pregnancy, because studies suggest it may cause fetal harm. For breastfeeding, there are no data on whether Istradefylline passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Aric?
Doctors have very little clinical experience of overdose with Istradefylline in people. If an overdose happens, Istradefylline should be stopped and supportive treatment given as the doctor sees fit. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Aric?
Store Istradefylline below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Aric?
Some medicines can interact with Istradefylline, for example: Rifampicin, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Aric is already among the lowest-priced brands of Istradefylline at this strength.
Do I need a prescription for Aric?
Aric is a prescription (Rx) medicine. Take it as your doctor advises.