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Community data Updated 23 hours ago

Insulin Glargine

Long Acting Insulin Prescription
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Indications

Type 2 Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus

Insulin Glargine is used to improve blood sugar control in adults and children with type 1 diabetes mellitus, and in adults with type 2 diabetes mellitus.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Insulin Glargine is a sterile solution that you inject under the skin (subcutaneous injection). It is a recombinant human insulin analogue, made by recombinant DNA technology, and it works as a long-acting blood glucose lowering medicine for injection, with a duration of action of up to 24 hours.

Its main job is to regulate glucose metabolism. Insulin glargine, like other insulins and their analogues, lowers blood glucose in two ways. It stimulates peripheral glucose uptake, mainly by skeletal muscle and fat, and it inhibits glucose production in the liver. Insulin also inhibits lipolysis and proteolysis, and it enhances protein synthesis.

Pregnancy & Breastfeeding

Insulin glargine is in pregnancy category C. That means it should be used during pregnancy only if the possible benefit to the mother justifies the possible risk to the fetus.

It is not known whether insulin glargine passes into human milk. Many drugs do, including human insulin, so a doctor should be careful when giving insulin glargine to a nursing woman. Women who are breastfeeding may need their insulin dose and their diet adjusted.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Insulin Glargine has a fairly steady glucose-lowering effect over 24 hours, so it can be given once a day. Its potency is about the same as human insulin. It is recommended as a once-daily subcutaneous injection and can be given at any time of the day, but once you start, give it at the same time every day. The dose must be individualized based on clinical response. Blood glucose monitoring is essential in all patients with diabetes. In patients with type 1 diabetes, it must be used in regimens with short-acting insulin. It is not recommended for intravenous use, because giving the usual subcutaneous dose intravenously could result in severe hypoglycemia. Initiation of Insulin Glargine therapy: in patients with type 1 diabetes, the recommended starting dose is approximately one-third of the total daily insulin requirements. Short-acting, premeal insulin should then cover the rest of the daily insulin requirements. In patients with type 2 diabetes who are not currently treated with insulin, the recommended starting dose is 10 units (or 0.2 Units/kg) once daily, and this should then be adjusted to the patient's needs. Converting to Insulin Glargine from other insulin therapies: if a patient changes from a regimen with an intermediate- or long-acting insulin, the amount and timing of shorter-acting insulins may need to be adjusted, and so may the doses of any oral anti-diabetic drugs. When moving a patient from once-daily NPH insulin, the recommended initial dose of Insulin Glargine is the same as the dose of NPH being discontinued. When moving a patient from twice-daily NPH insulin to once-daily Insulin Glargine, the recommended initial dose is 80% of the total NPH dose being discontinued.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.