Indapamide + Amlodipine

Indications

Hypertension

Indapamide + Amlodipine tablet is used to treat essential hypertension in patients whose blood pressure is already controlled with indapamide and amlodipine taken together at the same dose levels. It replaces the two separate medicines, so the patient takes one tablet instead.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Indapamide is a sulphonamide derivative with an indole ring, and it is pharmacologically related to the thiazide diuretics. It works by blocking the reabsorption of sodium in the cortical dilution segment. This raises the amount of sodium and chlorides passed in the urine, and to a lesser extent potassium and magnesium too. Urine output goes up as a result, and this gives the antihypertensive action.

Amlodipine belongs to the dihydropyridine group of calcium ion influx inhibitors (also called slow channel blockers or calcium ion antagonists). It stops calcium ions from moving across the cell membrane into cardiac and vascular smooth muscle. Its antihypertensive action comes from a direct relaxant effect on vascular smooth muscle.

Pregnancy & Breastfeeding

If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before you take this medicine. Indapamide + Amlodipine is not recommended during pregnancy. Once a pregnancy is planned or confirmed, your doctor should move you to a different treatment as soon as possible.

You must not take this medicine if you are breastfeeding. If you are breastfeeding or about to start, tell your doctor immediately.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Take one tablet a day, as a single dose, preferably in the morning. Swallow it whole with water and don't chew it. This fixed dose combination isn't suitable for starting treatment. If the dose needs to change, the titration should be done with the individual components. Pediatric population: The safety and efficacy of this medicine in children and adolescents have not been established, and no data are available. Patients with renal impairment: In severe renal impairment (creatinine clearance below 30 ml/min), treatment is contraindicated. In mild to moderate renal impairment, no dose adjustment is needed. Older people can be treated with this medicine according to their renal function. Patients with hepatic impairment: In severe hepatic impairment, treatment is contraindicated. Dosage recommendations of amlodipine have not been established in mild to moderate hepatic impairment, so the dose should be chosen with caution and should start at the lower end of the dosing range.