Pricing
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All price changes →Natrixam
Rx1.5 mg+5 mg • Tablet (Modified Release)
Indications & Uses
Natrixam is indicated for:
Pharmacology
Indapamide is a sulphonamide derivative with an indole ring, and it is pharmacologically related to the thiazide diuretics. It works by blocking the reabsorption of sodium in the cortical dilution segment. This raises the amount of sodium and chlorides passed in the urine, and to a lesser extent potassium and magnesium too. Urine output goes up as a result, and this gives the antihypertensive action.
Amlodipine belongs to the dihydropyridine group of calcium ion influx inhibitors (also called slow channel blockers or calcium ion antagonists). It stops calcium ions from moving across the cell membrane into cardiac and vascular smooth muscle. Its antihypertensive action comes from a direct relaxant effect on vascular smooth muscle.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take one tablet a day, as a single dose, preferably in the morning. Swallow it whole with water and don't chew it. This fixed dose combination isn't suitable for starting treatment. If the dose needs to change, the titration should be done with the individual components.
Pediatric population: The safety and efficacy of this medicine in children and adolescents have not been established, and no data are available.
Patients with renal impairment: In severe renal impairment (creatinine clearance below 30 ml/min), treatment is contraindicated. In mild to moderate renal impairment, no dose adjustment is needed. Older people can be treated with this medicine according to their renal function.
Patients with hepatic impairment: In severe hepatic impairment, treatment is contraindicated. Dosage recommendations of amlodipine have not been established in mild to moderate hepatic impairment, so the dose should be chosen with caution and should start at the lower end of the dosing range.
Side Effects
When indapamide and amlodipine are given separately, the side effects reported most often are somnolence, dizziness, headache, palpitations, flushing, abdominal pain, nausea, ankle swelling, oedema and fatigue.
Cautions & Contraindications
Warnings & Precautions
Before you take Indapamide + Amlodipine, tell your doctor if you have, or have ever had, any of these conditions: a recent heart attack, heart failure, or any heart rhythm problems. Also mention coronary artery disease (heart disease caused by poor blood flow in the blood vessels of the heart), kidney problems, or a severe increase in blood pressure (hypertensive crisis). Your doctor should know if you have liver problems, diabetes or gout, or if you are malnourished. Tell your doctor too if you are elderly and your dose needs to be increased, or if you take other medicines. The same goes if you need a test to check how well your parathyroid gland is working, or if you have had photosensitivity reactions.
Contraindications
Indapamide + Amlodipine must not be used in anyone with hypersensitivity to the active substances, to other sulphonamides, to dihydropyridine derivatives or to any of the excipients. It is also contraindicated in severe renal failure (creatinine clearance below 30 ml/min), hepatic encephalopathy or severe impairment of liver function, and hypokalaemia. Lactation is another contraindication, as are severe hypotension and shock (including cardiogenic shock). The same applies to obstruction of the outflow tract of the left ventricle (e.g., high-grade aortic stenosis) and to hemodynamically unstable heart failure after acute myocardial infarction.
Pregnancy & Breastfeeding
If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before you take this medicine. Indapamide + Amlodipine is not recommended during pregnancy. Once a pregnancy is planned or confirmed, your doctor should move you to a different treatment as soon as possible.
You must not take this medicine if you are breastfeeding. If you are breastfeeding or about to start, tell your doctor immediately.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Indapamide + Amlodipine below 30°C, away from light and moisture. Keep it out of the reach of children.
Common questions about Natrixam 1.5 mg+5 mg
What is Natrixam 1.5 mg+5 mg Tablet (Modified Release)?
Natrixam 1.5 mg+5 mg Tablet (Modified Release) is a medicine that contains Indapamide + Amlodipine. It is made by Servier Bangladesh Operation. It belongs to the Combined antihypertensive preparations group of medicines.
What is Natrixam used for?
Natrixam is used for: Hypertension.
What are the side effects of Natrixam?
When indapamide and amlodipine are given separately, the side effects reported most often are somnolence, dizziness, headache, palpitations, flushing, abdominal pain, nausea, ankle swelling, oedema and fatigue.
Can I take Natrixam during pregnancy or while breastfeeding?
If you are pregnant, breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before you take this medicine. Indapamide + Amlodipine is not recommended during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Natrixam?
Store Indapamide + Amlodipine below 30°C, away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Natrixam is already among the lowest-priced brands of Indapamide + Amlodipine at this strength.
Do I need a prescription for Natrixam?
Natrixam is a prescription (Rx) medicine. Take it as your doctor advises.