Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 23 hours ago

Indacaterol + Glycopyrronium

Combined bronchodilators Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Asthma Chronic Obstructive Pulmonary Disease Bronchitis

Indacaterol + Glycopyrronium is used as a long-term maintenance bronchodilator, taken once a day, for airflow obstruction in people with chronic obstructive pulmonary disease (COPD). This includes chronic bronchitis and emphysema. Don't use it in acute episodes of bronchospasm. It is also not indicated for asthma.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Indacaterol and glycopyrronium come as an inhalation powder, and the two medicines are delivered together by oral inhalation. Glycopyrronium is an anticholinergic and indacaterol is a LABA.

Beta2-adrenoceptor agonists such as indacaterol work, at least in part, by stimulating intracellular adenyl cyclase. This is the enzyme that converts adenosine triphosphate (ATP) to cyclic-3, 5-adenosine monophosphate (cyclic AMP). When cyclic AMP levels rise, the smooth muscle of the bronchi relaxes. The release of mediators of immediate hypersensitivity from cells, especially mast cells, is also inhibited.

Glycopyrronium is a long-acting muscarinic antagonist, often called an anticholinergic. Its affinity is similar across the muscarinic receptor subtypes M1 to M5. In the airways, it acts by inhibiting the M3 receptor on the smooth muscle, and this leads to bronchodilation.

Pregnancy & Breastfeeding

Indacaterol + Glycopyrronium falls under pregnancy category C. No data are available on its use in pregnant women, so it should be used during pregnancy only if the expected benefit to the patient justifies the potential risk to the foetus.

It isn't known whether Indacaterol or Glycopyrronium, or their metabolites, pass into human milk. Breast-feeding women should be given this combination only if the expected benefit to the woman is greater than any possible risk to the infant.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults (18 years or older): Indacaterol + Glycopyrronium is for oral inhalation only. Use it at the same time every day, and no more than once in 24 hours. Maintenance treatment of COPD: 1 inhalation once daily. Limitations of use: It is not indicated for relief of acute bronchospasm or for the treatment of asthma. Geriatric: The recommended dose can be used in elderly patients (65 years of age and older). Use in children and adolescents: It is not indicated for use in children and adolescents. Safety and efficacy have not been established in pediatric patients (aged 17 years and younger). Renal impairment: The recommended dose can be used in patients with mild to moderate renal impairment. In patients with severe renal impairment, or end-stage renal disease requiring dialysis (estimated glomerular filtration rate below 30 mL/min/1.73 m2), use it only if the expected benefit outweighs the potential risk. Hepatic impairment: The recommended dose can be used in patients with mild and moderate hepatic impairment. No data are available for patients with severe hepatic impairment, so caution should be observed in these patients.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.