Pricing
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All price changes →Oxima Plus
Rx110 mcg+50 mcg • Dry Powder Inhalation Capsule (DPI)
Indications & Uses
Oxima Plus is indicated for:
Pharmacology
Indacaterol and glycopyrronium come as an inhalation powder, and the two medicines are delivered together by oral inhalation. Glycopyrronium is an anticholinergic and indacaterol is a LABA.
Beta2-adrenoceptor agonists such as indacaterol work, at least in part, by stimulating intracellular adenyl cyclase. This is the enzyme that converts adenosine triphosphate (ATP) to cyclic-3, 5-adenosine monophosphate (cyclic AMP). When cyclic AMP levels rise, the smooth muscle of the bronchi relaxes. The release of mediators of immediate hypersensitivity from cells, especially mast cells, is also inhibited.
Glycopyrronium is a long-acting muscarinic antagonist, often called an anticholinergic. Its affinity is similar across the muscarinic receptor subtypes M1 to M5. In the airways, it acts by inhibiting the M3 receptor on the smooth muscle, and this leads to bronchodilation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults (18 years or older): Indacaterol + Glycopyrronium is for oral inhalation only. Use it at the same time every day, and no more than once in 24 hours.
Maintenance treatment of COPD: 1 inhalation once daily.
Limitations of use: It is not indicated for relief of acute bronchospasm or for the treatment of asthma.
Geriatric: The recommended dose can be used in elderly patients (65 years of age and older).
Use in children and adolescents: It is not indicated for use in children and adolescents. Safety and efficacy have not been established in pediatric patients (aged 17 years and younger).
Renal impairment: The recommended dose can be used in patients with mild to moderate renal impairment. In patients with severe renal impairment, or end-stage renal disease requiring dialysis (estimated glomerular filtration rate below 30 mL/min/1.73 m2), use it only if the expected benefit outweighs the potential risk.
Hepatic impairment: The recommended dose can be used in patients with mild and moderate hepatic impairment. No data are available for patients with severe hepatic impairment, so caution should be observed in these patients.
Side Effects
Side effects seen with muscarinic antagonists, one of the medicine types in Indacaterol + Glycopyrronium, include cardiovascular effects (atrial arrhythmias and tachycardia), eye disorders (e.g., blurred vision), urinary retention, gastrointestinal disorders, dry mouth and cough. Side effects seen with β2-agonists include immediate hypersensitivity reactions (urticaria, rash, bronchospasm, edema and angioedema), cardiovascular effects (tachycardia, arrhythmia, palpitations, myocardial ischaemia, hypertension or hypotension), hypokalemia, hyperglycemia, headache, nervousness, insomnia, muscle spasms, fatigue, malaise and tremor. The most common reactions related to the drug product itself (reported >3% and greater than placebo) were cough and oropharyngeal pain, which includes throat irritation.
Cautions & Contraindications
Warnings & Precautions
LABA monotherapy raises the risk of serious asthma-related events. Don't start Indacaterol + Glycopyrronium in people whose COPD or asthma is getting acutely worse, and don't use it to treat acute symptoms. Don't use it together with any other therapy that contains a LABA, because of the risk of overdose. If paradoxical bronchospasm occurs, stop the medicine and start alternative therapy. Because of beta-adrenergic stimulation, use it with caution in patients with cardiovascular disorders. Use caution too in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus and ketoacidosis. Narrow-angle glaucoma may get worse. Use it with caution in these patients, and tell them to contact a doctor immediately if symptoms occur. Urinary retention may also get worse. Use caution in patients with prostatic hyperplasia or bladder-neck obstruction, and they should contact a doctor immediately if symptoms occur. Watch for hypokalemia and hyperglycemia.
Contraindications
Indacaterol + Glycopyrronium must not be given to anyone who is hypersensitive to glycopyrronium or indacaterol, or to any other component of this combination. It is also contraindicated in patients with severe hypersensitivity to milk proteins. And all LABA are contraindicated in patients with asthma who are not using a long-term asthma control medicine.
Pregnancy & Breastfeeding
Indacaterol + Glycopyrronium falls under pregnancy category C. No data are available on its use in pregnant women, so it should be used during pregnancy only if the expected benefit to the patient justifies the potential risk to the foetus.
It isn't known whether Indacaterol or Glycopyrronium, or their metabolites, pass into human milk. Breast-feeding women should be given this combination only if the expected benefit to the woman is greater than any possible risk to the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no information on clinically relevant overdosing with Indacaterol + Glycopyrronium. If someone does take too much, the effects typical of β2-adrenergic stimulants may become exaggerated. These include tachycardia, tremor, palpitations, headache, nausea, vomiting, drowsiness, ventricular arrhythmias, metabolic acidosis, hypokalemia and hyperglycaemia. Anticholinergic effects could also appear, such as increased intraocular pressure (causing pain, vision disturbances or reddening of the eye), obstipation or difficulties in voiding. Supportive and symptomatic treatment is indicated, and in serious cases the patient should be hospitalized.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Indacaterol + Glycopyrronium away from direct sunlight and heat. A cool, dry place is best. Don't let it get into the eyes. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Oxima Plus 110 mcg+50 mcg
What is Oxima Plus 110 mcg+50 mcg Dry Powder Inhalation Capsule (DPI)?
Oxima Plus 110 mcg+50 mcg Dry Powder Inhalation Capsule (DPI) is a medicine that contains Indacaterol + Glycopyrronium. It is made by Advanced Chemical Industries PLC. It belongs to the Combined bronchodilators group of medicines.
What is Oxima Plus used for?
Oxima Plus is used for: Asthma, Chronic Obstructive Pulmonary Disease, Bronchitis.
What are the side effects of Oxima Plus?
Side effects seen with muscarinic antagonists, one of the medicine types in Indacaterol + Glycopyrronium, include cardiovascular effects (atrial arrhythmias and tachycardia), eye disorders (e.g., blurred vision), urinary retention, gastrointestinal disorders, dry mouth and cough. Side effects seen with β2-agonists include immediate hypersensitivity reactions (urticaria, rash, bronchospasm, edema and angioedema), cardiovascular effects (tachycardia, arrhythmia, palpitations, myocardial ischaemia, hypertension or hypotension), hypokalemia, hyperglycemia, headache, nervousness, insomnia, muscle spasms, fatigue, malaise and tremor.
Can I take Oxima Plus during pregnancy or while breastfeeding?
Indacaterol + Glycopyrronium falls under pregnancy category C. No data are available on its use in pregnant women, so it should be used during pregnancy only if the expected benefit to the patient justifies the potential risk to the foetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Oxima Plus?
There is no information on clinically relevant overdosing with Indacaterol + Glycopyrronium. If someone does take too much, the effects typical of β2-adrenergic stimulants may become exaggerated. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Oxima Plus?
Keep Indacaterol + Glycopyrronium away from direct sunlight and heat. A cool, dry place is best.
Can I take other medicines with Oxima Plus?
Some medicines can interact with Indacaterol + Glycopyrronium, for example: Indacaterol, Glycopyrronium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Oxima Plus is already among the lowest-priced brands of Indacaterol + Glycopyrronium at this strength.
Do I need a prescription for Oxima Plus?
Oxima Plus is a prescription (Rx) medicine. Take it as your doctor advises.