Community data Updated 2 months ago

Iloperidone

Piperidinyl-benzisoxazole derivative Prescription

Indications

Schizophrenia

Ilodon is an atypical antipsychotic indicated for the treatment of schizophrenia in adults, and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Iloperidone binds strongly to dopamine D2 receptors in the caudate nucleus and putamen of the brains of people with schizophrenia, and it occupies these receptors to the maximum extent. The improvement in cognition is put down to iloperidone's strong affinity for α adrenergic receptors. It also binds strongly to serotonin 5-HT2a and dopamine D3 receptors. Its binding to dopamine D4, serotonin 5-HT6 and 5-HT7, and norepinephrine NEα1 receptors is moderate. Iloperidone binds only weakly to serotonin 5-HT1A, dopamine D1, and histamine H1 receptors.

Pregnancy & Breastfeeding

Pregnancy: Exposure during the third trimester may cause extrapyramidal and/or withdrawal symptoms in the newborn.

Lactation: It is not known whether iloperidone or its metabolites pass into human breast milk, nor is it known what effect this may have on a breastfed child or on milk production. Iloperidone has been found to pass into the milk of rats.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Iloperidone must be titrated slowly to avoid orthostatic hypotension. Because of this need to titrate slowly, control of symptoms may be delayed during the first 1 to 2 weeks of treatment. Administer Iloperidone orally twice daily, without regard to meals, and titrate the dosage to avoid orthostatic hypotension. For schizophrenia, the starting dosage is 1 mg twice daily and the recommended dosage is 6 mg to 12 mg twice daily. For bipolar mania, the starting dosage is 1 mg twice daily and the recommended dosage is 12 mg twice daily. In children and adolescents, safety and effectiveness have not been established. Iloperidone is not recommended for patients with severe hepatic impairment.