Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Pain Osteoarthritis

Hylan G-F 20 is used to treat pain from osteoarthritis (OA) of the knee. It's meant for patients who haven't responded well enough to conservative nonpharmacologic therapy and simple analgesics, such as acetaminophen.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Joints contain a fluid called synovial fluid, which works as a lubricant and a shock absorber. In people with osteoarthritis this fluid is thinner than normal, so it doesn't lubricate or absorb shock as well. Hylan G-F 20 is an elastic fluid made from hyaluronan, a substance found in normal joint fluid. Hyaluronan is the key substance that gives joint fluid its shock-absorbing quality, and joints need it to work properly. When Hylan G-F 20 is injected into the knee of a patient with osteoarthritis, it helps restore the shock-absorbing effect of the fluid in the knee. This can reduce pain and allow a more active lifestyle.

Pregnancy & Breastfeeding

Nobody has established that Hylan G-F 20 is safe or effective for use in pregnant women. It's also not known whether Hylan G-F 20 passes into human milk, and its safety and effectiveness in women who are breastfeeding have not been established either.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Hylan G-F 20 is given as an injection into the joint (intra-articular), once a week for a total of three injections, with one week between each. Follow a strict aseptic technique throughout. Before each Hylan G-F 20 injection, remove any synovial fluid or effusion using an 18- to 22-gauge needle. Don't use the same syringe for removing the fluid and for injecting Hylan G-F 20, though the same 18- to 22-gauge needle should be used for both. Twist the tip cap before you pull it off, because this reduces leakage of the product. To get a tight seal and prevent leakage during the injection, hold the luer hub firmly and secure the needle tightly. Pediatrics: The safety and effectiveness of Hylan G-F have not been established in pediatric patients. Pediatric patients are defined as patients ≤ 21 years of age.