Indications & Uses
Synvisc-One is indicated for:
Pharmacology
Joints contain a fluid called synovial fluid, which works as a lubricant and a shock absorber. In people with osteoarthritis this fluid is thinner than normal, so it doesn't lubricate or absorb shock as well. Hylan G-F 20 is an elastic fluid made from hyaluronan, a substance found in normal joint fluid. Hyaluronan is the key substance that gives joint fluid its shock-absorbing quality, and joints need it to work properly. When Hylan G-F 20 is injected into the knee of a patient with osteoarthritis, it helps restore the shock-absorbing effect of the fluid in the knee. This can reduce pain and allow a more active lifestyle.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Hylan G-F 20 is given as an injection into the joint (intra-articular), once a week for a total of three injections, with one week between each. Follow a strict aseptic technique throughout.
Before each Hylan G-F 20 injection, remove any synovial fluid or effusion using an 18- to 22-gauge needle. Don't use the same syringe for removing the fluid and for injecting Hylan G-F 20, though the same 18- to 22-gauge needle should be used for both.
Twist the tip cap before you pull it off, because this reduces leakage of the product. To get a tight seal and prevent leakage during the injection, hold the luer hub firmly and secure the needle tightly.
Pediatrics: The safety and effectiveness of Hylan G-F have not been established in pediatric patients. Pediatric patients are defined as patients ≤ 21 years of age.
Side Effects
The side effects reported most often with Hylan G-F 20 are pain in the injected knee, swelling in the injected knee, and joint effusion.
Cautions & Contraindications
Warnings & Precautions
The effectiveness of a single treatment cycle with fewer than three injections (2 mL each) of Hylan G-F 20 has not been established. Its safety and effectiveness haven't been established in any joint other than the knee, or for any condition other than osteoarthritis. Nor have they been established when it is used together with other intra-articular injectables. Take care when injecting patients who are allergic to avian proteins, feathers and egg products. Safety and effectiveness in severely inflamed knee joints have also not been established. Strict aseptic technique must be followed. STERILE CONTENTS. The syringe is for single use, and its contents must be used immediately after the packaging is opened. Discard any unused Hylan G-F 20, and don't use it if the package is opened or damaged. Store it in the original packaging (protected from light) at room temperature below 86°F (30°C). DO NOT FREEZE. Remove any synovial fluid or effusion before each injection. Use caution if there is evidence of lymphatic or venous stasis in the leg to be injected. Don't use disinfectants containing quaternary ammonium salts for skin preparation at the same time, because hyaluronan can precipitate in their presence. Do not inject the product outside the joint (extra-articularly) or into the synovial tissues and capsule. Local and systemic adverse events, generally in the area of the injection, have occurred after extra-articular injection. Injection into a blood vessel (intravascular) may cause systemic adverse events.
Contraindications
Hylan G-F 20 must not be given to anyone who is known to be allergic (hypersensitive) to hyaluronan preparations, which include sodium hyaluronate. It also must not be injected into the knee if the joint is infected, or if there is a skin disease or infection at the injection site.
Pregnancy & Breastfeeding
Nobody has established that Hylan G-F 20 is safe or effective for use in pregnant women. It's also not known whether Hylan G-F 20 passes into human milk, and its safety and effectiveness in women who are breastfeeding have not been established either.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Don't use Hylan G-F 20 if the package has already been opened or is damaged. Keep it in its original packaging, away from light, at room temperature below 86°F (30°C). Do not freeze it.
Common questions about Synvisc-One 48 mg/10 ml
What is Synvisc-One 48 mg/10 ml Intra-articular Injection?
Synvisc-One 48 mg/10 ml Intra-articular Injection is a medicine that contains Hylan G-F 20. It is made by Synovia Pharma PLC. It belongs to the Drugs for Osteoarthritis group of medicines.
What is Synvisc-One used for?
Synvisc-One is used for: Pain, Osteoarthritis.
What are the side effects of Synvisc-One?
The side effects reported most often with Hylan G-F 20 are pain in the injected knee, swelling in the injected knee, and joint effusion.
Can I take Synvisc-One during pregnancy or while breastfeeding?
Nobody has established that Hylan G-F 20 is safe or effective for use in pregnant women. It's also not known whether Hylan G-F 20 passes into human milk, and its safety and effectiveness in women who are breastfeeding have not been established either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Synvisc-One?
Don't use Hylan G-F 20 if the package has already been opened or is damaged. Keep it in its original packaging, away from light, at room temperature below 86°F (30°C).
Do I need a prescription for Synvisc-One?
Synvisc-One is a prescription (Rx) medicine. Take it as your doctor advises.