Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 22 hours ago

Human Papillomavirus Bivalent

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Indications

Cancer

Human Papillomavirus Bivalent is for women aged 9 to 45 years. It helps prevent diseases caused by the cancer-causing human papillomavirus (HPV) types 16 and/or 18. These are cervical cancer, cervical intraepithelial neoplasia Grade 2 or 3 (CIN2/3) and adenocarcinoma in-situ (AIS), and cervical intraepithelial neoplasia Grade 1 (CIN1) and persistent infections of HPV types 16 and/or 18. HPvax is used in the same way, for women aged 9 to 45 years, to prevent the same diseases caused by oncogenic HPV types 16 and/or 18. The risk of exposure to HPV goes up with age, especially once a person becomes sexually active. So the vaccine should be given as early as possible. Getting it earlier, anywhere between 9 and 45 years of age, is more beneficial.

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

Pregnancy: So far, no independent study has looked at the effect of Human Papillomavirus Bivalent vaccine on pregnant women. There is very limited data from a clinical trial, and it showed that accidental vaccination during pregnancy did not cause abnormal pregnancy outcomes or neonatal health problems. No adverse effects were seen on pregnancy rate, pregnancy outcomes or neonatal health after the HPV vaccine was given. Still, the data are not enough to say whether pregnant women face a risk of adverse pregnancy outcomes (including spontaneous abortion) after vaccination. In animal experiments, no direct or indirect adverse effects were seen on reproduction, pregnancy, embryo/fetus development, parturition or postnatal development. Vaccination should be avoided during pregnancy. If a woman is pregnant or preparing for pregnancy, it is recommended to postpone or interrupt the vaccination procedure, and she can be vaccinated after the pregnancy ends.

Lactation: There is no relevant study data for the HPV vaccine. Many drugs can pass into breast milk, so the HPV vaccine should be used with caution in lactating women.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The Human Papillomavirus Bivalent vaccine is given as 3 doses of 0.5 ml each, by intramuscular injection, at 0, 1 and 6 months. If the schedule needs some flexibility, the second dose can be given between 1 month and 2 months after the first dose, and the third dose between 5 and 8 months after the first dose. Based on clinical trial results and the recommendations in Human Papillomavirus Vaccines: WHO Position Paper (2017), females aged 9 to 14 years can also choose a two-dose schedule, at 0 month and 6 month. Each dose is 0.5 ml, and the gap between the two doses must be not less than 5 months. At present, nobody has determined whether a booster is required. The full course is 3 doses of 0.5 ml each, by intramuscular injection, at 0, 1 and 6 months. The preferred site is the deltoid region of the upper arm. There is no data on subcutaneous injection. Intravascular or intradermal injection is prohibited. Before giving the vaccine, look at the prefilled syringe both before and after shaking, and check for any foreign particles and/or an abnormal appearance. If you see either, discard the vaccine. Shake it well before use. After shaking it should be a white, even suspension. Give it as soon as possible after taking it out of the refrigeration container, and use the full recommended dose. Don't use a prefilled syringe that has a crack or an unclear or invalid label, or a vaccine that looks abnormal.