Indications & Uses
Papilovax is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The Human Papillomavirus Bivalent vaccine is given as 3 doses of 0.5 ml each, by intramuscular injection, at 0, 1 and 6 months. If the schedule needs some flexibility, the second dose can be given between 1 month and 2 months after the first dose, and the third dose between 5 and 8 months after the first dose. Based on clinical trial results and the recommendations in Human Papillomavirus Vaccines: WHO Position Paper (2017), females aged 9 to 14 years can also choose a two-dose schedule, at 0 month and 6 month. Each dose is 0.5 ml, and the gap between the two doses must be not less than 5 months. At present, nobody has determined whether a booster is required.
The full course is 3 doses of 0.5 ml each, by intramuscular injection, at 0, 1 and 6 months. The preferred site is the deltoid region of the upper arm. There is no data on subcutaneous injection. Intravascular or intradermal injection is prohibited.
Before giving the vaccine, look at the prefilled syringe both before and after shaking, and check for any foreign particles and/or an abnormal appearance. If you see either, discard the vaccine. Shake it well before use. After shaking it should be a white, even suspension. Give it as soon as possible after taking it out of the refrigeration container, and use the full recommended dose. Don't use a prefilled syringe that has a crack or an unclear or invalid label, or a vaccine that looks abnormal.
Side Effects
Human Papillomavirus Bivalent (Types 16 and 18) vaccine is generally well tolerated. Pain, redness and swelling at the injection site were the most common local adverse reactions. Among general adverse events, fatigue, headache, myalgia, gastrointestinal symptoms and arthralgia were reported most often. Systemic Adverse Reactions: Very common: Fever (≥37.1°C) Common: Headache, fatigue, cough, muscle pain, nausea, diarrhea, dizziness and vomiting Occasional: Hypersensitivity, allergic dermatitis, rash, dizziness and pruritus. Local Adverse Reactions: Very common: Pain at the injection site Common: Pruritus, induration, swelling and erythema at injection site Occasional: Rash and discomfort at injection site. Most of these adverse reactions are mild to moderate.
Cautions & Contraindications
Contraindications
Don't give Human Papillomavirus Bivalent vaccine to anyone who is hypersensitive to the active substances or to any of the excipients in the vaccine. It should also not be given to people who showed signs of hypersensitivity after an earlier dose of this vaccine.
Pregnancy & Breastfeeding
Pregnancy: So far, no independent study has looked at the effect of Human Papillomavirus Bivalent vaccine on pregnant women. There is very limited data from a clinical trial, and it showed that accidental vaccination during pregnancy did not cause abnormal pregnancy outcomes or neonatal health problems. No adverse effects were seen on pregnancy rate, pregnancy outcomes or neonatal health after the HPV vaccine was given. Still, the data are not enough to say whether pregnant women face a risk of adverse pregnancy outcomes (including spontaneous abortion) after vaccination. In animal experiments, no direct or indirect adverse effects were seen on reproduction, pregnancy, embryo/fetus development, parturition or postnatal development. Vaccination should be avoided during pregnancy. If a woman is pregnant or preparing for pregnancy, it is recommended to postpone or interrupt the vaccination procedure, and she can be vaccinated after the pregnancy ends.
Lactation: There is no relevant study data for the HPV vaccine. Many drugs can pass into breast milk, so the HPV vaccine should be used with caution in lactating women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Human Papillomavirus Bivalent vaccine out of the reach and sight of children. Store it at +2ºC to +8ºC, and keep the same temperature range when it is being transported. Don't freeze it. If the vaccine has been frozen, discard it. Protect it from light.
Common questions about Papilovax 0.5 ml
What is Papilovax 0.5 ml IM Injection?
Papilovax 0.5 ml IM Injection is a medicine that contains Human Papillomavirus Bivalent. It is made by Incepta Pharmaceuticals Ltd.
What is Papilovax used for?
Papilovax is used for: Cancer.
What are the side effects of Papilovax?
Human Papillomavirus Bivalent (Types 16 and 18) vaccine is generally well tolerated. Pain, redness and swelling at the injection site were the most common local adverse reactions.
Can I take Papilovax during pregnancy or while breastfeeding?
Pregnancy: So far, no independent study has looked at the effect of Human Papillomavirus Bivalent vaccine on pregnant women. There is very limited data from a clinical trial, and it showed that accidental vaccination during pregnancy did not cause abnormal pregnancy outcomes or neonatal health problems. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Papilovax?
Keep Human Papillomavirus Bivalent vaccine out of the reach and sight of children. Store it at +2ºC to +8ºC, and keep the same temperature range when it is being transported.
Do I need a prescription for Papilovax?
Papilovax is a prescription (Rx) medicine. Take it as your doctor advises.