Indications
Human Anti-D Immunoglobulins are used in Rh-negative women for pregnancy and other obstetrical conditions, unless the father or the baby is conclusively Rh negative. These conditions are: Pregnancy or delivery of an Rh-positive baby, whatever the ABO groups of the mother and baby are Abortion or threatened abortion at any stage of gestation Ectopic pregnancy Antepartum fetal-maternal hemorrhage (suspected or proven) that results from antepartum hemorrhage (for example, placenta previa), amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling, another obstetrical manipulative procedure (for example, version) or abdominal trauma Transfusion of Rh incompatible blood or blood products Human Anti-D Immunoglobulins are also used in transfusion, to prevent Rh immunization in any Rh-negative person after an incompatible transfusion of Rh-positive blood or blood products (for example, red blood cells, platelet concentrates, granulocyte concentrates).
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Anti-D immunoglobulin stops a rhesus-negative mother from making her own antibodies against rhesus-positive red blood cells (RBCs) from the baby. These cells can get into the mother's blood during childbirth, abortion or certain other sensitising events. The medicine is also used in idiopathic thrombocytopenic purpura, where it helps prevent excessive bleeding.
Pregnancy & Breastfeeding
Human Anti-D Immunoglobulins fall under Pregnancy Category C. This means either animal studies have shown harmful effects on the foetus (teratogenic, embryocidal or other), and there are no controlled studies in women, or no studies are available in women or in animals. The medicine should be given only if the possible benefit justifies the possible risk to the foetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.