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Halobetasol Propionate

Other Topical corticosteroids Prescription
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Indications

Psoriasis

Halobetasol Propionate 0.05% cream or ointment is a super-high potent corticosteroid used to relieve the inflammation and itching seen in dermatoses that respond to corticosteroid treatment. It should not be used beyond two consecutive weeks, and the total amount used should not exceed 50 gm per week, because of the potential for the drug to suppress the Hypothalamic-Pituitary-Adrenal (HPA) axis. The 0.01% lotion is likewise a super-high potent corticosteroid used to relieve the inflammation and itching of corticosteroid-responsive dermatoses, including plaque psoriasis, and it may be used continuously for up to 8 weeks.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Like other topical corticosteroids, halobetasol propionate works through anti-inflammatory, antipruritic and vasoconstrictive actions. The exact mechanism behind the anti-inflammatory effect of topical corticosteroids in general is still not fully understood. However, it is believed that corticosteroids act by inducing phospholipase A2 inhibitory proteins, known collectively as lipocortins. These proteins are thought to regulate the production of powerful inflammatory mediators such as prostaglandins and leukotrienes by blocking the release of their shared precursor, arachidonic acid. Arachidonic acid itself is released from membrane phospholipids through the action of phospholipase A2.

Pregnancy & Breastfeeding

Topical corticosteroids should be used in pregnancy only when the expected benefit outweighs any possible risk to the unborn baby. It is also not known whether using this medicine on the skin leads to enough absorption into the bloodstream to appear in breast milk. For this reason, it should be used with caution by breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: 0.05% Halobetasol Propionate: Apply a thin layer of halobetasol cream or ointment to the affected skin once or twice a day, as your doctor directs. Rub it in gently and completely. Halobetasol 0.05% is a super-high potency corticosteroid, so treatment should be limited to two weeks, and no more than 50 gm per week should be used. As with other highly active corticosteroids, stop the medicine once the condition is under control. If there is no improvement within 2 weeks, the diagnosis may need to be checked again. Do not use halobetasol under occlusive dressings. 0.01% Halobetasol Propionate: Apply a thin layer of halobetasol propionate lotion to the affected areas once a day and rub it in gently. Wash your hands after each application, unless the lotion is being used to treat the hands. Treatment with this lotion beyond 8 weeks is not recommended, and the total amount should not go over about 50 g per week. Stop treatment if the condition is under control before 8 weeks. Do not use it under occlusive dressings unless a doctor tells you to. This lotion should not be used on the face, groin or armpits. It is not for oral, eye or intravaginal use.