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Griseofulvin [Ultra Microsize]

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Indications

Fungal Infection

Griseofulvin Ultramicrosize is used to treat tinea infections. These include tinea corporis, onychomycosis, tinea pedis, tinea cruris, tinea barbae, tinea capitis and similar infections.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Griseofulvin is an antibiotic taken by mouth, and it comes from a species of Penicillium. Doctors use it to treat tinea infections. Its effect on fungi is fungistatic, meaning it stops them growing. It does this by disrupting the mitotic spindle structure of the fungal cell, which arrests metaphase in cell division.

After you swallow it, griseofulvin settles in the keratin precursor cells and has a greater affinity for diseased tissue. It binds tightly to the new keratin, and that keratin becomes highly resistant to fungal invasions.

The ultra microsize form (ultramicrocrystalline griseofulvin) is absorbed from the gastrointestinal tract about one and one-half times as efficiently as conventional microsize griseofulvin. Because of this, the oral dose can be two-thirds of what is needed with the microsize form. However, there is currently no evidence that this lower dose makes any significant clinical difference in safety and/or efficacy.

Pregnancy & Breastfeeding

Doctors should not prescribe griseofulvin (Ultra Microsize) to pregnant patients. If a patient becomes pregnant while taking it, she should be told about the possible danger to the fetus.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For adults, griseofulvin (ultramicrosize) is given at 375 mg, either as a single dose or in divided doses. The length of treatment depends on the infection. Tinea capitis needs 4 to 6 weeks, tinea corporis 2 to 4 weeks, and tinea pedis 4 to 8 weeks. Tinea cruris uses the same 375 mg, single or divided. Nail infections need a higher dose. For fingernail onychomycosis, the dose is 750 mg in divided doses for at least 4 months. For toenail onychomycosis, it's 750 mg in divided doses for at least 6 months. In children, approximately 7.3 mg per kg of body weight per day of ultramicrosize griseofulvin is an effective dose for most patients. On this basis, the suggested schedule is 125 mg to 187.5 mg daily for children weighing 16 to 27 kg, and 187.5 mg to 375 mg daily for those over 27 kg. For children and infants 2 years of age and younger, the dose has not been established. Clinical experience in children with tinea capitis shows that a single daily dose of griseofulvin works. The medicine must be continued until the infecting organism is eradicated, because clinical relapse will occur if it is stopped earlier.