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These brands contain the same active ingredient (Griseofulvin [Ultra Microsize]). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Griseofulvin is indicated for:
Pharmacology
Griseofulvin is an antibiotic taken by mouth, and it comes from a species of Penicillium. Doctors use it to treat tinea infections. Its effect on fungi is fungistatic, meaning it stops them growing. It does this by disrupting the mitotic spindle structure of the fungal cell, which arrests metaphase in cell division.
After you swallow it, griseofulvin settles in the keratin precursor cells and has a greater affinity for diseased tissue. It binds tightly to the new keratin, and that keratin becomes highly resistant to fungal invasions.
The ultra microsize form (ultramicrocrystalline griseofulvin) is absorbed from the gastrointestinal tract about one and one-half times as efficiently as conventional microsize griseofulvin. Because of this, the oral dose can be two-thirds of what is needed with the microsize form. However, there is currently no evidence that this lower dose makes any significant clinical difference in safety and/or efficacy.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, griseofulvin (ultramicrosize) is given at 375 mg, either as a single dose or in divided doses. The length of treatment depends on the infection. Tinea capitis needs 4 to 6 weeks, tinea corporis 2 to 4 weeks, and tinea pedis 4 to 8 weeks. Tinea cruris uses the same 375 mg, single or divided.
Nail infections need a higher dose. For fingernail onychomycosis, the dose is 750 mg in divided doses for at least 4 months. For toenail onychomycosis, it's 750 mg in divided doses for at least 6 months.
In children, approximately 7.3 mg per kg of body weight per day of ultramicrosize griseofulvin is an effective dose for most patients. On this basis, the suggested schedule is 125 mg to 187.5 mg daily for children weighing 16 to 27 kg, and 187.5 mg to 375 mg daily for those over 27 kg. For children and infants 2 years of age and younger, the dose has not been established.
Clinical experience in children with tinea capitis shows that a single daily dose of griseofulvin works. The medicine must be continued until the infecting organism is eradicated, because clinical relapse will occur if it is stopped earlier.
Side Effects
Griseofulvin (ultra microsize) can occasionally cause oral thrush, nausea, vomiting, epigastric distress and diarrhea. Headache, fatigue, dizziness and insomnia are also reported from time to time, along with mental confusion and impairment of performance of routine activities. Proteinuria and leukopenia have been reported rarely.
Cautions & Contraindications
Warnings & Precautions
Anyone who stays on a potent medicine for a long time should be watched closely. With Griseofulvin [Ultra Microsize], the doctor should check how the organ systems are working from time to time, including the kidneys, the liver and the blood-forming system. Griseofulvin [Ultra Microsize] comes from species of Penicillium, so cross sensitivity with penicillin is possible. That said, people known to be sensitive to penicillin have been treated with it without difficulty. The medicine occasionally causes a photosensitivity reaction, so patients should be warned to avoid intense natural or artificial sunlight. Lupus erythematosus and lupus-like syndromes have been reported in patients taking it. It also lowers the activity of warfarin-type anticoagulants. A patient taking one of these together with Griseofulvin [Ultra Microsize] may need the anticoagulant dose adjusted, both during and after the course. Barbiturates usually reduce the activity of Griseofulvin [Ultra Microsize], so if they are given together, the dose of the antifungal may need adjusting.
Contraindications
Griseofulvin should not be given to people with porphyria or hepatocellular failure. It is also not for anyone who has had a hypersensitivity reaction to griseofulvin in the past.
Pregnancy & Breastfeeding
Doctors should not prescribe griseofulvin (Ultra Microsize) to pregnant patients. If a patient becomes pregnant while taking it, she should be told about the possible danger to the fetus.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Griseofulvin [Ultra Microsize] out of reach of children. Store it in a dry place, below 25°C, and protect it from light.
Common questions about Griseofulvin 500 mg
What is Griseofulvin 500 mg Tablet?
Griseofulvin 500 mg Tablet is a medicine that contains Griseofulvin [Ultra Microsize]. It is made by APC Pharma Limited. It belongs to the Other Antifungal preparations group of medicines.
What is Griseofulvin used for?
Griseofulvin is used for: Fungal Infection.
What are the side effects of Griseofulvin?
Griseofulvin (ultra microsize) can occasionally cause oral thrush, nausea, vomiting, epigastric distress and diarrhea. Headache, fatigue, dizziness and insomnia are also reported from time to time, along with mental confusion and impairment of performance of routine activities.
Can I take Griseofulvin during pregnancy or while breastfeeding?
Doctors should not prescribe griseofulvin (Ultra Microsize) to pregnant patients. If a patient becomes pregnant while taking it, she should be told about the possible danger to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Griseofulvin?
Keep Griseofulvin [Ultra Microsize] out of reach of children. Store it in a dry place, below 25°C, and protect it from light.
Is there a cheaper medicine with the same ingredient?
G-G Vin by Gonoshasthaya Pharmaceuticals Ltd. has the same ingredient and strength for ৳4.00 per unit, compared with ৳5.50 for Griseofulvin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Griseofulvin?
Griseofulvin is a prescription (Rx) medicine. Take it as your doctor advises.