Furosemide

Adults: Furosemide 40 mg tablet for edema. Adults: the initial dose is 40 mg daily, which is then reduced to 20 mg daily or 40 mg on alternate days. Some patients may need daily doses of 80 mg or higher, given in divided doses. Once the single dose has been worked out for the patient, it should be given once or twice daily (for example, at 8 am and 2 pm). For resistant edema, the dose is 80 to 120 mg daily. In patients with clinically severe edematous states, the dose of furosemide may be carefully titrated up to 600 mg/day. When doses above 80 mg/day are given for a long time, careful clinical observation and laboratory monitoring are particularly advisable. Children: Neonate: 0.5 to 2 mg/kg every 12 to 24 hours (every 24 hours if postmenstrual age is under 31 weeks). Child 1 month to 12 years: 0.5 to 2 mg/kg 2 to 3 times daily (every 24 hours if postmenstrual age is less than 31 weeks). Higher doses may be required in resistant edema, with a max. of 12 mg/kg daily, not to exceed 80 mg daily. Child 12 to 18 years: 20 to 40 mg daily, increased in resistant edema to 80 to 120 mg daily. Elderly: furosemide is generally eliminated more slowly in the elderly, so the dose should be titrated until the required response is reached. Hypertension: Adults: the usual starting dose of furosemide for hypertension is 80 mg, usually divided into 40 mg twice a day. The dose is then adjusted according to response. If the response is not satisfactory, other antihypertensive agents should be added. Children: the usual dose is 1 to 3 mg/kg body weight daily, up to a maximum of 40 mg/day. Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached. Furosemide 250 mg tablet: in selected patients with advanced chronic renal failure, diuretic therapy may be started with oral furosemide. If conventional doses (80 to 160 mg orally) fail to produce an adequate diuresis, a single dose of 250 mg is given as the starting dose. If a satisfactory diuresis does not follow within 4 to 6 hours, the initial dose may be doubled to 500 mg. The aim is a urinary output of at least 2.5 liters per day. A maximum daily dose of 1000 mg should not be exceeded. Furosemide syrup: furosemide liquid has a very wide therapeutic range, and the effect is proportional to the dose. It is best given as a single dose, either daily or on alternate days. The usual initial daily dose is 40 mg. This may need adjusting until the effective dose is found, and that then becomes the maintenance dose. In mild cases, 20 mg daily or 40 mg on alternate days may be enough. In resistant edema, daily doses of 80 mg and above may be used, given as one or two doses daily, or intermittently. Severe cases may need gradual titration of the furosemide dose up to 600 mg daily. The recommended maximum daily dose of furosemide is 1,500 mg. Furosemide injection for edema. Adults: doses of 20 to 50 mg may be given initially, intramuscularly or intravenously. If larger doses are required, they should be increased in steps of 20 mg and not given more often than every two hours. If doses greater than 50 mg are required, it is recommended that they be given by slow intravenous infusion. The recommended maximum daily dose of furosemide is 1,500 mg. By slow intravenous injection: Neonate: 0.5 to 1 mg/kg every 12 to 24 hours (every 24 hours if postmenstrual age is under 31 weeks). Child 1 month to 12 years: 0.5 to 1 mg/kg repeated every 8 hours as necessary, maximum 2 mg/kg (max. 40 mg) every 8 hours. Child 12 to 18 years: 20 to 40 mg repeated every 8 hours as necessary, and higher doses may be required in resistant cases. By continuous intravenous infusion: Child 1 month to 18 years: 0.1 to 2 mg/kg/hour (following cardiac surgery, initially 100 micrograms/kg/hour, doubled every 2 hours until urine output exceeds 1 mL/kg/hour). Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached. Hypertension: Adults: doses of 20 to 50 mg may be given initially, intramuscularly or intravenously. If larger doses are required, they should be increased in steps of 20 mg and not given more often than every two hours. If doses greater than 50 mg are required, it is recommended that they be given by slow intravenous infusion. The recommended maximum daily dose of furosemide is 1,500 mg. Children: parenteral doses range from 0.5 to 1.5 mg/kg body weight daily, up to a maximum total daily dose of 20 mg. Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached.