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These brands contain the same active ingredient (Furosemide). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Frusin
Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Frusin is indicated for:
Pharmacology
Furosemide is a monosulphonyl diuretic. It works well even when the glomerular filtration rate (GFR) is low, so it keeps its activity there. Its action on renal tubular function is distinctive, and it produces a peak diuresis far greater than other agents do. Other features are (I) a prompt onset of action, (II) inhibition of sodium and chloride transport in the ascending limb of the loop of Henle, and (III) an action that doesn't depend on acid-base balance changes. Furosemide acts mainly by inhibiting electrolyte reabsorption in the thick ascending limb of the loop of Henle. The gastrointestinal tract absorbs furosemide readily, and a considerable proportion binds to plasma proteins. The urine clears it rapidly. Within an hour after intravenous injection, the effect shows in about 5 minutes and lasts for about 2 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Furosemide 40 mg tablet for edema. Adults: the initial dose is 40 mg daily, which is then reduced to 20 mg daily or 40 mg on alternate days. Some patients may need daily doses of 80 mg or higher, given in divided doses. Once the single dose has been worked out for the patient, it should be given once or twice daily (for example, at 8 am and 2 pm). For resistant edema, the dose is 80 to 120 mg daily. In patients with clinically severe edematous states, the dose of furosemide may be carefully titrated up to 600 mg/day. When doses above 80 mg/day are given for a long time, careful clinical observation and laboratory monitoring are particularly advisable. Children: Neonate: 0.5 to 2 mg/kg every 12 to 24 hours (every 24 hours if postmenstrual age is under 31 weeks). Child 1 month to 12 years: 0.5 to 2 mg/kg 2 to 3 times daily (every 24 hours if postmenstrual age is less than 31 weeks). Higher doses may be required in resistant edema, with a max. of 12 mg/kg daily, not to exceed 80 mg daily. Child 12 to 18 years: 20 to 40 mg daily, increased in resistant edema to 80 to 120 mg daily. Elderly: furosemide is generally eliminated more slowly in the elderly, so the dose should be titrated until the required response is reached. Hypertension: Adults: the usual starting dose of furosemide for hypertension is 80 mg, usually divided into 40 mg twice a day. The dose is then adjusted according to response. If the response is not satisfactory, other antihypertensive agents should be added. Children: the usual dose is 1 to 3 mg/kg body weight daily, up to a maximum of 40 mg/day. Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached.
Furosemide 250 mg tablet: in selected patients with advanced chronic renal failure, diuretic therapy may be started with oral furosemide. If conventional doses (80 to 160 mg orally) fail to produce an adequate diuresis, a single dose of 250 mg is given as the starting dose. If a satisfactory diuresis does not follow within 4 to 6 hours, the initial dose may be doubled to 500 mg. The aim is a urinary output of at least 2.5 liters per day. A maximum daily dose of 1000 mg should not be exceeded.
furosemide liquid has a very wide therapeutic range, and the effect is proportional to the dose. It is best given as a single dose, either daily or on alternate days. The usual initial daily dose is 40 mg. This may need adjusting until the effective dose is found, and that then becomes the maintenance dose. In mild cases, 20 mg daily or 40 mg on alternate days may be enough. In resistant edema, daily doses of 80 mg and above may be used, given as one or two doses daily, or intermittently. Severe cases may need gradual titration of the furosemide dose up to 600 mg daily. The recommended maximum daily dose of furosemide is 1,500 mg.
Furosemide injection for edema. Adults: doses of 20 to 50 mg may be given initially, intramuscularly or intravenously. If larger doses are required, they should be increased in steps of 20 mg and not given more often than every two hours. If doses greater than 50 mg are required, it is recommended that they be given by slow intravenous infusion. The recommended maximum daily dose of furosemide is 1,500 mg.
Neonate: 0.5 to 1 mg/kg every 12 to 24 hours (every 24 hours if postmenstrual age is under 31 weeks). Child 1 month to 12 years: 0.5 to 1 mg/kg repeated every 8 hours as necessary, maximum 2 mg/kg (max. 40 mg) every 8 hours. Child 12 to 18 years: 20 to 40 mg repeated every 8 hours as necessary, and higher doses may be required in resistant cases.
Child 1 month to 18 years: 0.1 to 2 mg/kg/hour (following cardiac surgery, initially 100 micrograms/kg/hour, doubled every 2 hours until urine output exceeds 1 mL/kg/hour). Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached. Hypertension: Adults: doses of 20 to 50 mg may be given initially, intramuscularly or intravenously. If larger doses are required, they should be increased in steps of 20 mg and not given more often than every two hours. If doses greater than 50 mg are required, it is recommended that they be given by slow intravenous infusion. The recommended maximum daily dose of furosemide is 1,500 mg. Children: parenteral doses range from 0.5 to 1.5 mg/kg body weight daily, up to a maximum total daily dose of 20 mg. Elderly: furosemide is generally eliminated more slowly, so the dose should be titrated until the required response is reached.
Side Effects
Like other diuretics, furosemide can upset the balance of electrolytes and water in the body when it's taken for a long time, because of the increased urine output. Long-term use can also lead to alkalosis. Furosemide may cause uric acid to be retained too, and in rare cases this can bring on acute gout. It can also raise blood sugar (hyperglycemia) and cause sugar to appear in the urine (glycosuria).
Cautions & Contraindications
Warnings & Precautions
People with prostatic hypertrophy or difficulty passing urine have a higher risk of acute retention when they take Furosemide. If an ACE inhibitor is added to Furosemide treatment, blood pressure can fall sharply. Potent diuretics such as Furosemide, when given together with nephrotoxic antibiotics, may increase the toxic effects of those antibiotics. Driving a vehicle or performing other hazardous tasks Some adverse effects, for example an undesirably pronounced fall in blood pressure, may affect a patient's ability to concentrate and react. This can be a risk where those abilities matter a great deal, such as when operating a vehicle or machinery.
Contraindications
Furosemide must not be used in people with anuria, electrolyte deficiency, or pre-comatose states linked to liver cirrhosis. It is also not suitable for anyone who is hypersensitive to furosemide or to sulphonamides.
Pregnancy & Breastfeeding
Furosemide is pregnancy category C. Use it with caution in the first trimester of pregnancy, and also in cardiogenic shock complicated by pulmonary oedema. Blood pressure and pulse should be monitored during rapid diuresis. Take care with patients who are liable to electrolyte deficiency.
For a nursing mother, furosemide may inhibit lactation or may pass into breast milk. So it should be used with caution in that case too.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Signs and symptoms: In an acute or chronic Furosemide overdose, the picture depends mainly on how much fluid and electrolyte the body has lost and what that loss leads to. This can mean hypovolaemia, dehydration, haemoconcentration and cardiac arrhythmias (including AV block and ventricular fibrillation).
Management: There is no known specific antidote to Furosemide. If the tablets have only just been taken, you can try to limit how much more of the active ingredient gets into the blood. Gastric lavage is one way, and so are measures that reduce absorption, such as activated charcoal.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Furosemide away from light. Don't use it after the expiry date. Keep all medicines out of the reach of children. It should be dispensed only on the prescription of a registered physician.
Drug Interactions
Common questions about Frusin 40 mg
What is Frusin 40 mg Tablet?
Frusin 40 mg Tablet is a medicine that contains Furosemide. It is made by Opsonin Pharma Limited. It belongs to the Loop diuretics group of medicines.
What is Frusin used for?
Frusin is used for: Hypertension, Heart Failure, Edema.
What are the side effects of Frusin?
Like other diuretics, furosemide can upset the balance of electrolytes and water in the body when it's taken for a long time, because of the increased urine output. Long-term use can also lead to alkalosis.
Can I take Frusin during pregnancy or while breastfeeding?
Furosemide is pregnancy category C. Use it with caution in the first trimester of pregnancy, and also in cardiogenic shock complicated by pulmonary oedema. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Frusin?
Signs and symptoms: In an acute or chronic Furosemide overdose, the picture depends mainly on how much fluid and electrolyte the body has lost and what that loss leads to. This can mean hypovolaemia, dehydration, haemoconcentration and cardiac arrhythmias (including AV block and ventricular fibrillation). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Frusin?
Keep Furosemide away from light. Don't use it after the expiry date.
Can I take other medicines with Frusin?
Some medicines can interact with Furosemide, for example: Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C, Naproxen Sodium, Vildagliptin + Metformin Hydrochloride, Furosemide + Spironolactone, Dobutamine Hydrochloride, Metformin Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Frudema by Pacific Pharmaceuticals Ltd. has the same ingredient and strength for ৳0.53 per unit, compared with ৳1.00 for Frusin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Frusin?
Frusin is a prescription (Rx) medicine. Take it as your doctor advises.