Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Fluocinolone Acetonide + Hydroquinone + Tretinoin

Hydroquinone Preparations Prescription
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Indications

Fluocinolone Acetonide + Hydroquinone + Tretinoin cream is used for the short-term treatment of moderate to severe melasma of the face. Once you start the treatment, stay out of the sun as much as you can. Use a sunscreen of at least SPF 30 or more.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

This cream contains three active ingredients: Fluocinolone Acetonide, Hydroquinone and Tretinoin. All three are used to treat melasma. How the combination works in melasma is not known, but each ingredient has its own therapeutic class. Fluocinolone Acetonide is a corticosteroid for use on the skin and is classed as an anti-inflammatory. Hydroquinone is classed as a depigmenting agent, and it may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. Tretinoin is classed as a keratolytic agent.

Pregnancy & Breastfeeding

Pregnancy Category C. This cream (Fluocinolone Acetonide + Hydroquinone + Tretinoin) contains tretinoin, a teratogen, which may cause embryo-fetal death, altered fetal growth, congenital malformations and potential neurologic deficits. Animal studies on teratogenicity are hard to interpret for this cream, because the amount absorbed through the skin in those studies can't be assured and the results can't be compared with clinical dosing. There are no adequate and well controlled studies in pregnant women. The cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: When corticosteroids are given systemically, the drug appears in human milk. It is not known whether applying this cream to the skin could lead to enough systemic absorption to produce detectable amounts of Fluocinolone Acetonide, Hydroquinone or Tretinoin in human milk. Because many drugs are secreted in human milk, caution should be exercised when this cream is given to nursing women.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Apply the Fluocinolone Acetonide + Hydroquinone + Tretinoin cream once daily at night, at least 30 minutes before bedtime. Start by washing the face and neck gently with a mild cleanser, then rinse and pat the skin dry. Spread a thin film of the cream over the hyperpigmented areas of melasma, including about ½ inch of normal-appearing skin around each lesion. Rub it in lightly and evenly. During the day, use sunscreen and wear protective clothing. Avoid sunlight exposure. Patients may use moisturisers and/or cosmetics during the day. Pediatric use: the safety and effectiveness of this cream in pediatric patients have not been established.