Pricing
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All price changes →Indications & Uses
Fluocinolone Acetonide + Hydroquinone + Tretinoin cream is used for the short-term treatment of moderate to severe melasma of the face. Once you start the treatment, stay out of the sun as much as you can. Use a sunscreen of at least SPF 30 or more.
Pharmacology
This cream contains three active ingredients: Fluocinolone Acetonide, Hydroquinone and Tretinoin. All three are used to treat melasma. How the combination works in melasma is not known, but each ingredient has its own therapeutic class. Fluocinolone Acetonide is a corticosteroid for use on the skin and is classed as an anti-inflammatory. Hydroquinone is classed as a depigmenting agent, and it may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. Tretinoin is classed as a keratolytic agent.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Apply the Fluocinolone Acetonide + Hydroquinone + Tretinoin cream once daily at night, at least 30 minutes before bedtime. Start by washing the face and neck gently with a mild cleanser, then rinse and pat the skin dry. Spread a thin film of the cream over the hyperpigmented areas of melasma, including about ½ inch of normal-appearing skin around each lesion. Rub it in lightly and evenly.
During the day, use sunscreen and wear protective clothing. Avoid sunlight exposure. Patients may use moisturisers and/or cosmetics during the day.
Pediatric use: the safety and effectiveness of this cream in pediatric patients have not been established.
Side Effects
A small number of patients may have a severe allergic reaction to this cream, with trouble breathing or severe asthma attacks. While using the cream, the skin can also become mildly to moderately red, peel, burn, feel dry or itch.
Cautions & Contraindications
Warnings & Precautions
This cream contains Hydroquinone and Tretinoin, and these two can cause mild to moderate irritation. You may expect some local irritation where the cream is applied, such as skin reddening, peeling, a mild burning sensation, dryness and pruritus. Transient skin reddening or a mild burning sensation does not rule out treatment. But if a reaction looks like hypersensitivity or chemical irritation, stop using the medicine. The cream also contains Fluocinolone Acetonide, which is a corticosteroid. When a topical corticosteroid is absorbed into the body, it can cause reversible Hypothalamic-Pituitary-Adrenal (HPA) axis suppression, and there is a chance of glucocorticosteroid insufficiency after treatment is withdrawn. Absorption into the body can also produce signs of Cushing's syndrome, hyperglycemia and glucosuria while treatment is going on. If HPA axis suppression is noted, stop using this cream. HPA axis function generally recovers once the topical corticosteroid is discontinued.
Contraindications
Don't use this cream if you have ever had a hypersensitivity, allergy or intolerance to this product (fluocinolone acetonide + hydroquinone + tretinoin) or to any of its components.
Pregnancy & Breastfeeding
Pregnancy Category C. This cream (Fluocinolone Acetonide + Hydroquinone + Tretinoin) contains tretinoin, a teratogen, which may cause embryo-fetal death, altered fetal growth, congenital malformations and potential neurologic deficits. Animal studies on teratogenicity are hard to interpret for this cream, because the amount absorbed through the skin in those studies can't be assured and the results can't be compared with clinical dosing. There are no adequate and well controlled studies in pregnant women. The cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: When corticosteroids are given systemically, the drug appears in human milk. It is not known whether applying this cream to the skin could lead to enough systemic absorption to produce detectable amounts of Fluocinolone Acetonide, Hydroquinone or Tretinoin in human milk. Because many drugs are secreted in human milk, caution should be exercised when this cream is given to nursing women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep this medicine in a cool, dry place away from light. Don't let it freeze. Keep it out of reach of children.
Common questions about Brite 0.01%+4%+0.05%
What is Brite 0.01%+4%+0.05% Cream?
Brite 0.01%+4%+0.05% Cream is a medicine that contains Fluocinolone Acetonide + Hydroquinone + Tretinoin. It is made by Euro Pharma Ltd. It belongs to the Hydroquinone Preparations group of medicines.
What is Brite used for?
Fluocinolone Acetonide + Hydroquinone + Tretinoin cream is used for the short-term treatment of moderate to severe melasma of the face. Once you start the treatment, stay out of the sun as much as you can.
What are the side effects of Brite?
A small number of patients may have a severe allergic reaction to this cream, with trouble breathing or severe asthma attacks. While using the cream, the skin can also become mildly to moderately red, peel, burn, feel dry or itch.
Can I take Brite during pregnancy or while breastfeeding?
Pregnancy Category C. This cream (Fluocinolone Acetonide + Hydroquinone + Tretinoin) contains tretinoin, a teratogen, which may cause embryo-fetal death, altered fetal growth, congenital malformations and potential neurologic deficits. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Brite?
Keep this medicine in a cool, dry place away from light. Don't let it freeze.
Do I need a prescription for Brite?
Brite is a prescription (Rx) medicine. Take it as your doctor advises.