Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Fezolinetant

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Indications

Fezolinetant tablet is used to treat moderate to severe vasomotor symptoms that come with menopause.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Fezolinetant is a neurokinin 3 (NK3) receptor antagonist. It blocks neurokinin B (NKB) from binding on the kisspeptin/neurokinin B/dynorphin (KNDy) neuron, and this changes the activity of neurons in the thermoregulatory center. Fezolinetant binds strongly to the NK3 receptor (Ki value of 19.9 to 22.1 nmol/L), and this affinity is more than 450-fold higher than its binding to NK1 or NK2 receptors.

In menopausal women, treatment with fezolinetant did not show any clear trends in the sex hormones that were measured (follicle-stimulating hormone, testosterone, estrogen, and dehydroepiandrosterone sulfate). A transient decrease in luteinizing hormone (LH) levels was seen at the peak concentrations of fezolinetant.

Pregnancy & Breastfeeding

No data exist on the use of Fezolinetant in pregnant women, so it isn't possible to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. Nothing is known about breastfeeding either. There are no data on whether fezolinetant passes into human milk, what effect it might have on a breastfed child, or whether it changes milk production.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Take one 45 mg Fezolinetant tablet by mouth once a day, with or without food. Swallow it whole with liquids. Don't cut, crush or chew the tablet. Try to take Fezolinetant at about the same time each day. If you miss a dose, or don't take it at the usual time, take the missed dose as soon as you can. The one exception is when there are less than 12 hours left before the next scheduled dose. Then go back to your regular schedule the following day. Pediatric Use: The efficacy and safety of Fezolinetant in people under 18 years of age have not been established. Geriatric Use: Not enough women over 65 years of age have taken part in clinical trials of Fezolinetant to show whether they respond differently from younger women.