Pricing
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All price changes →Indications & Uses
Fezolinetant tablet is used to treat moderate to severe vasomotor symptoms that come with menopause.
Pharmacology
Fezolinetant is a neurokinin 3 (NK3) receptor antagonist. It blocks neurokinin B (NKB) from binding on the kisspeptin/neurokinin B/dynorphin (KNDy) neuron, and this changes the activity of neurons in the thermoregulatory center. Fezolinetant binds strongly to the NK3 receptor (Ki value of 19.9 to 22.1 nmol/L), and this affinity is more than 450-fold higher than its binding to NK1 or NK2 receptors.
In menopausal women, treatment with fezolinetant did not show any clear trends in the sex hormones that were measured (follicle-stimulating hormone, testosterone, estrogen, and dehydroepiandrosterone sulfate). A transient decrease in luteinizing hormone (LH) levels was seen at the peak concentrations of fezolinetant.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take one 45 mg Fezolinetant tablet by mouth once a day, with or without food. Swallow it whole with liquids. Don't cut, crush or chew the tablet. Try to take Fezolinetant at about the same time each day.
If you miss a dose, or don't take it at the usual time, take the missed dose as soon as you can. The one exception is when there are less than 12 hours left before the next scheduled dose. Then go back to your regular schedule the following day.
Pediatric Use: The efficacy and safety of Fezolinetant in people under 18 years of age have not been established.
Geriatric Use: Not enough women over 65 years of age have taken part in clinical trials of Fezolinetant to show whether they respond differently from younger women.
Side Effects
The common side effects of Fezolinetant are stomach (abdominal) pain, diarrhea, difficulty sleeping, back pain, and hot flashes or hot flushes. Stop Fezolinetant if you notice signs or symptoms of liver problems. These are nausea, vomiting, itching, yellowing of the eyes or skin (jaundice), pale feces, dark urine, and pain in the right upper stomach (abdomen).
Cautions & Contraindications
Warnings & Precautions
Hepatic transaminase elevation and hepatotoxicity are the main cautions with Fezolinetant. In the clinical trials, serum transaminase concentrations rose to more than 3 times the upper limit of normal (ULN). So liver blood tests should be done before Fezolinetant is started, to check how well the liver is working and whether there is any liver injury. A patient should not start Fezolinetant if the alanine aminotransferase (ALT) or aspartate aminotransferase (AST) concentration is equal to or above 2 times the ULN. The same applies if the total bilirubin is elevated (for example, equal to or above 2 times the ULN) for the laboratory doing the test. After starting, the patient should have follow-up liver blood tests every month for the first 3 months, then at 6 months and at 9 months.
Contraindications
Fezolinetant is contraindicated in women with any of these conditions: known cirrhosis, severe renal impairment or end-stage renal disease, or concomitant use with CYP1A2 inhibitors.
Pregnancy & Breastfeeding
No data exist on the use of Fezolinetant in pregnant women, so it isn't possible to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. Nothing is known about breastfeeding either. There are no data on whether fezolinetant passes into human milk, what effect it might have on a breastfed child, or whether it changes milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much Fezolinetant, the treatment is to stop the medicine and give care for whatever symptoms appear.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Fezolinetant below 30°C, away from light, and out of the reach of children.
Common questions about Fizora 45 mg
What is Fizora 45 mg Tablet?
Fizora 45 mg Tablet is a medicine that contains Fezolinetant. It is made by Incepta Pharmaceuticals Ltd.
What is Fizora used for?
Fezolinetant tablet is used to treat moderate to severe vasomotor symptoms that come with menopause.
What are the side effects of Fizora?
The common side effects of Fezolinetant are stomach (abdominal) pain, diarrhea, difficulty sleeping, back pain, and hot flashes or hot flushes. Stop Fezolinetant if you notice signs or symptoms of liver problems.
Can I take Fizora during pregnancy or while breastfeeding?
No data exist on the use of Fezolinetant in pregnant women, so it isn't possible to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. Nothing is known about breastfeeding either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Fizora?
If someone takes too much Fezolinetant, the treatment is to stop the medicine and give care for whatever symptoms appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Fizora?
Keep Fezolinetant below 30°C, away from light, and out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Fizora is already among the lowest-priced brands of Fezolinetant at this strength.
Do I need a prescription for Fizora?
Fizora is a prescription (Rx) medicine. Take it as your doctor advises.