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Community data Updated 2 months ago

Fexofenadine Hydrochloride

Non-sedating antihistamines Prescription
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Indications

Allergic Rhinitis Urticaria

Allergic rhinitis: Fenox is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, in adults and children 12 years of age and over. Symptoms treated effectively include sneezing, rhinorrhea, lacrimation, itchy, red eyes and itchy nose/palate/throat. Fenox improves health related quality of life and work/activity productivity. Chronic idiopathic urticaria: Fenox is indicated for the relief of symptoms associated with chronic idiopathic urticaria in adults and children 12 years of age and older. Fenox significantly reduces the signs and symptoms of chronic idiopathic urticaria, the number of wheals, and pruritus. Fenox improves health related quality of life and work/activity productivity.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

The H1 histamine receptor mediates hypersensitivity and allergic reactions. When a person is exposed to an allergen, mast cells and basophils degranulate and release histamine along with other inflammatory mediators. Histamine then binds to and activates H1 receptors, and this triggers the further release of pro-inflammatory cytokines, such as interleukins, from the basophils and mast cells. These downstream effects of histamine binding cause many of the common allergic symptoms, such as pruritus, rhinorrhea and watery eyes.

Fexofenadine hydrochloride is called an "inverse agonist" of the H1 receptor. It binds to the inactive form of the receptor and stabilizes it, so the receptor can't be activated and the downstream effects don't follow. Its affinity for H1 receptors is potent and selective, and there is no evidence that it has antidopaminergic, antiserotonergic, anticholinergic, sedative or adrenergic blocking activity. Fexofenadine does not cross the blood-brain barrier, so significant CNS effects are unlikely.

Pregnancy & Breastfeeding

Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Even so, this medicine should only be used during pregnancy if it is clearly needed.

There's no data on whether Fexofenadine hydrochloride passes into human breast milk. However, when the related drug Terfenadine was given to breastfeeding mothers, Fexofenadine was found to pass into breast milk. For this reason, breastfeeding mothers are advised not to use Fexofenadine hydrochloride.

No human data are available on how this medicine affects fertility. In mice, Fexofenadine hydrochloride treatment did not affect fertility.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Allergic rhinitis Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily. Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily. Children from 2 to 11 years take the suspension as 30 mg (5 ml) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml) once daily. Chronic idiopathic urticaria Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily. Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily. Children from 6 months to less than 2 years take the suspension as 15 mg (2.5 ml, which is 1/2 tsp) twice daily. If kidney function is impaired, the dose is 15 mg (2.5 ml, 1/2 tsp) once daily. Children from 2 to 11 years take the suspension as 30 mg (5 ml, which is 1 tsp) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml, 1 tsp) once daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.