Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Zactrol contains famotidine and is used to treat gastric ulcer, duodenal ulcer, anastomotic ulcer, and acute stress ulcer, as well as reflux esophagitis and Zollinger-Ellison syndrome. It is also used to treat acute gastritis and flare-ups of chronic gastritis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Famotidine belongs to a class of medicines called H2-receptor antagonists. It works by completely blocking the action of histamine on the H2-receptors found in the acid-producing cells of the stomach lining. Through this action, it reduces acid secretion that would otherwise occur at baseline, overnight, and in response to pentagastrin stimulation. Because famotidine separates only slowly from these H2-receptors once bound, its acid-suppressing effect also wears off gradually rather than stopping abruptly.

Pregnancy & Breastfeeding

Famotidine has been placed in pregnancy category B. There are no adequate, well-controlled studies in pregnant women, so the medicine should be used during pregnancy only when it is clearly needed. Care is also needed when famotidine is given to a woman who is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Tablet For gastric ulcer, duodenal ulcer, anastomotic ulcer, upper gastro-intestinal hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome, the usual adult dose of Famotidine is 20 mg twice daily, after breakfast and after supper or before bed time. Famotidine 40 mg can also be taken orally once daily at bed time. For acute gastritis and chronic gastritis in the acute exacerbation stage, the usual adult dose is Famotidine 20 mg orally twice a day, after breakfast and after supper or before bed time. Famotidine 40 mg can also be taken orally once a day before bed time. The dose should be adjusted according to age and symptoms. Most ulcer patients heal within 4 to 8 weeks. For maintenance therapy, the recommended oral dose is 20 mg once daily. Or, as directed by the registered physician. Powder for Suspension Gastroesophageal Reflux Disease (GERD), patients under 1 year of age: 0.5 mg/kg/dose of famotidine oral suspension once daily, for up to 8 weeks. Age 3 to 11 months: 0.5 mg/kg/dose twice daily, for up to 8 weeks. Age 1 to 2 months: 0.5 mg/kg/dose once daily, for up to 8 weeks. Neonates: 0.5 mg/kg/dose, once daily at most, for up to 8 weeks. Patients 1 to 16 years of age: Gastroesophageal Reflux Disease (GERD): 1 mg/kg/day p.o. divided b.i.d., up to 40 mg b.i.d. Duodonal ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d., up to 40 mg/day. Peptic ulcer: 0.5 mg/kg/day p.o. at bedtime or divided b.i.d., up to 40 mg/day. Maintenance therapy: 40 mg every night. Reflux esophagitis: 2 mg/kg/day. Zollinger-Ellison Syndrome: 40 mg 3 times daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.