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Ezetimibe

Ezetimibe Prescription
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Indications

Hyperlipidemia

Primary Hypercholesterolemia Ezetrol is given together with a statin, alongside diet, for patients with primary hypercholesterolemia (both heterozygous familial and non-familial) whose cholesterol is not properly controlled with a statin alone. Ezetrol can also be used by itself, again alongside diet, in patients with primary (heterozygous familial and non-familial) hypercholesterolemia when a statin is considered inappropriate or is not tolerated. Prevention of Cardiovascular Events Ezetrol is used to reduce the risk of cardiovascular events in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS). It is added to ongoing statin therapy, or it can be started at the same time as a statin. Homozygous Familial Hypercholesterolaemia (HoFH) Ezetrol is given with a statin, alongside diet, for patients with HoFH. These patients may also receive other treatments as well, for example LDL apheresis. Homozygous Sitosterolemia (Phytosterolemia) Ezetrol is used alongside diet in patients with homozygous familial sitosterolemia.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ezetimibe works at the brush border of the small intestine, where it blocks cholesterol absorption by acting on the sterol transporter Niemann-Pick C1-Like1 (NPC1L1). Less cholesterol then reaches the liver, hepatic cholesterol stores fall, and clearance of cholesterol from the blood increases.

Pregnancy & Breastfeeding

Pregnancy: Ezetimibe should only be used in pregnancy if it is clearly needed, as no clinical data exist on its use in pregnant women. Animal studies of ezetimibe used alone have not shown any direct or indirect harm to pregnancy, embryo-foetal development, birth, or development after birth.

Breastfeeding: Ezetimibe should not be used while breastfeeding. Studies in rats have shown that ezetimibe passes into breast milk; whether it passes into human breast milk is not known.

Fertility: No clinical data are available. Non-clinical studies have not shown any effect on fertility.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The patient should follow a suitable lipid lowering diet and continue this diet throughout treatment with Ezetimibe. Adult Dose: The recommended dose is one Ezetimibe 10 mg tablet once daily. Ezetimibe can be taken at any time of day, with or without food. Use in the elderly: No dosage adjustment is required for elderly patients. Pediatric Use: For pediatric patients aged 10 to 17 years, no dosage adjustment is required, though clinical experience in pediatric and adolescent patients remains limited. When Ezetimibe is given together with a statin, the dosing instructions for that statin in adolescents should be consulted. For pediatric patients below age 10, Ezetimibe is not recommended, since safety and efficacy data in this age group are insufficient. Use in hepatic impairment: No dosage adjustment is required for patients with mild hepatic insufficiency (Child Pugh score 5 to 6). Treatment with Ezetimibe is not recommended for patients with moderate (Child Pugh score 7 to 9) or severe (Child Pugh score above 9) liver dysfunction. Use in renal impairment: No dosage adjustment is required for patients with renal impairment.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.