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Estradiol Hemihydrate + Progesterone Micronized

Drugs for menopausal symptoms: Hormone replacement therapy Prescription

Indications

Estradiol Hemihydrate + Progesterone Micronized capsule is used in continuous combined Hormone Replacement Therapy (HRT) to treat symptoms of estrogen deficiency. It is meant for postmenopausal women who still have their uterus and whose last menstrual period was at least 12 months ago.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Estradiol Hemihydrate with Progesterone Micronized works by replacing hormones the body makes less of after menopause. Natural estrogens in the body are largely responsible for the development and maintenance of the female reproductive system and the secondary sexual characteristics. They act by binding to nuclear receptors in estrogen-responsive tissues.

The ovaries make estradiol, and this is controlled by the pituitary gonadotropins, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Estrogens circulating in the blood modulate LH and FSH through a negative feedback mechanism. In menopausal women, the ovarian follicles are depleted, so plasma estradiol falls while plasma FSH and LH rise.

Progesterone is added because it opposes the development of endometrial hyperplasia.

Pregnancy & Breastfeeding

Estradiol Hemihydrate + Progesterone Micronized is not recommended during pregnancy, labor or delivery, or for mothers who are breast feeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult: Take one capsule by mouth each evening, with food. Pediatrics: This capsule has not been studied in this patient group, so it is not recommended. Geriatrics: This capsule has not been studied in this patient group either, and it is not recommended. Hepatic Insufficiency: Don't give this capsule to women with liver dysfunction or liver disease while their liver function tests have not returned to normal. It is contraindicated in them. Renal Insufficiency: Use this capsule with caution in women with renal dysfunction.