Pricing
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All price changes →Dizuva
Rx1 mg+100 mg • Capsule
Indications & Uses
Estradiol Hemihydrate + Progesterone Micronized capsule is used in continuous combined Hormone Replacement Therapy (HRT) to treat symptoms of estrogen deficiency. It is meant for postmenopausal women who still have their uterus and whose last menstrual period was at least 12 months ago.
Pharmacology
Estradiol Hemihydrate with Progesterone Micronized works by replacing hormones the body makes less of after menopause. Natural estrogens in the body are largely responsible for the development and maintenance of the female reproductive system and the secondary sexual characteristics. They act by binding to nuclear receptors in estrogen-responsive tissues.
The ovaries make estradiol, and this is controlled by the pituitary gonadotropins, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Estrogens circulating in the blood modulate LH and FSH through a negative feedback mechanism. In menopausal women, the ovarian follicles are depleted, so plasma estradiol falls while plasma FSH and LH rise.
Progesterone is added because it opposes the development of endometrial hyperplasia.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult: Take one capsule by mouth each evening, with food.
Pediatrics: This capsule has not been studied in this patient group, so it is not recommended.
Geriatrics: This capsule has not been studied in this patient group either, and it is not recommended.
Hepatic Insufficiency: Don't give this capsule to women with liver dysfunction or liver disease while their liver function tests have not returned to normal. It is contraindicated in them.
Renal Insufficiency: Use this capsule with caution in women with renal dysfunction.
Side Effects
Common side effects of Estradiol Hemihydrate + Progesterone Micronized are hair loss, nausea, abdominal pain, headache, fatigue, flatulence and dizziness. Vaginal bleeding, vaginal discharge, uterine spasm, pelvic pain and breast pain can also happen. Rare side effects are ear swelling, vertigo, hirsutism, dry eye, blurred vision, visual impairment, vitreous floaters, cholelithiasis and unstable angina.
Cautions & Contraindications
Warnings & Precautions
Some women on HRT find their blood pressure goes up, so it should be checked regularly while they use it. If blood pressure rises in patients who were normotensive before, or in patients who already had hypertension, the cause should be investigated and HRT may have to be stopped. Estrogens, with or without progestins, may cause fluid retention. For this reason, take particular caution in patients with cardiac or renal dysfunction or asthma. Patients who develop visual disturbances, classical migraine, transient aphasia, paralysis or loss of consciousness should stop the medicine.
Contraindications
Estradiol Hemihydrate + Progesterone Micronized should not be used by people who are hypersensitive to this medicine or to any ingredient in the formulation, including any non-medicinal ingredient or part of the container. It is also not for patients with liver dysfunction or liver disease where liver function tests have not returned to normal. The medicine must not be given to anyone with a history of estrogen-dependent or progestogen-dependent malignant neoplasia, or to patients with endometrial hyperplasia. Other contraindications are undiagnosed abnormal genital bleeding, pregnancy and breastfeeding. Patients with a history of arterial thromboembolic disease should not take it, and the same applies to patients with classical migraine.
Pregnancy & Breastfeeding
Estradiol Hemihydrate + Progesterone Micronized is not recommended during pregnancy, labor or delivery, or for mothers who are breast feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much Estradiol Hemihydrate + Progesterone Micronized capsule may cause feeling sick, breast discomfort, fluid retention, bloating and vaginal bleeding. Some people also feel sad or tired, or notice acne and excess hair growth.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store the medicine at a temperature not above 25°C, and keep it away from light. Always keep it out of the reach of children.
Common questions about Dizuva 1 mg+100 mg
What is Dizuva 1 mg+100 mg Capsule?
Dizuva 1 mg+100 mg Capsule is a medicine that contains Estradiol Hemihydrate + Progesterone Micronized. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Drugs for menopausal symptoms: Hormone replacement therapy group of medicines.
What is Dizuva used for?
Estradiol Hemihydrate + Progesterone Micronized capsule is used in continuous combined Hormone Replacement Therapy (HRT) to treat symptoms of estrogen deficiency. It is meant for postmenopausal women who still have their uterus and whose last menstrual period was at least 12 months ago.
What are the side effects of Dizuva?
Common side effects of Estradiol Hemihydrate + Progesterone Micronized are hair loss, nausea, abdominal pain, headache, fatigue, flatulence and dizziness. Vaginal bleeding, vaginal discharge, uterine spasm, pelvic pain and breast pain can also happen.
Can I take Dizuva during pregnancy or while breastfeeding?
Estradiol Hemihydrate + Progesterone Micronized is not recommended during pregnancy, labor or delivery, or for mothers who are breast feeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dizuva?
Taking too much Estradiol Hemihydrate + Progesterone Micronized capsule may cause feeling sick, breast discomfort, fluid retention, bloating and vaginal bleeding. Some people also feel sad or tired, or notice acne and excess hair growth. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dizuva?
Store the medicine at a temperature not above 25°C, and keep it away from light. Always keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Dizuva is already among the lowest-priced brands of Estradiol Hemihydrate + Progesterone Micronized at this strength.
Do I need a prescription for Dizuva?
Dizuva is a prescription (Rx) medicine. Take it as your doctor advises.