Indications & Uses
Esomeprazole + Amoxicillin + Clarithromycin is used to clear (eradicate) H. pylori infection in people with active chronic gastric ulcers, duodenal ulcers and gastric ulcers.
Pharmacology
Esomeprazole lowers stomach acid by blocking the last step of acid production. It binds covalently to the sulfhydryl groups of cysteines on the (H+, K+)-ATPase enzyme, which sits at the secretory surface of the gastric parietal cells. This inhibits both basal and stimulated gastric acid secretion, whatever the stimulus. The binding is irreversible, and new enzyme has to be expressed before acid secretion can start again. So the antisecretory effect of esomeprazole lasts longer than 24 hours.
Amoxicillin is similar to penicillin in the way it kills bacteria. It acts on susceptible bacteria during the stage of active multiplication. It inhibits cell wall biosynthesis, and this leads to the death of the bacteria.
Clarithromycin works by inhibiting microsomal protein synthesis in susceptible organisms. It does this mainly by binding to the donor site on the 50S subunit of the bacterial ribosome, which prevents translocation to that site.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take one tablet twice daily for 7 to 14 days, or as your physician advises.
Side Effects
Most people tolerate H. pylori eradication therapy with Esomeprazole, Amoxicillin and Clarithromycin well. The side effects seen in clinical trials were what you would expect from the three medicines in the combination, so nothing unexpected turned up. The common ones were diarrhoea and nausea.
Cautions & Contraindications
Warnings & Precautions
Serious hypersensitivity reactions, some of them fatal, have been reported in patients taking Amoxicillin. They are more likely in people who have had a hypersensitivity reaction to penicillin before. Clarithromycin should not be used in pregnant women, unless the situation is one where no other treatment is suitable.
Contraindications
Esomeprazole + Amoxicillin + Clarithromycin must not be given to anyone who is known to be hypersensitive to any of its components.
Pregnancy & Breastfeeding
Esomeprazole + Amoxicillin + Clarithromycin should be given to a pregnant woman only when its use is considered essential. For breastfeeding, nobody has established yet whether this combination is safe for the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Geriatric use: This regimen of Esomeprazole + Amoxicillin + Clarithromycin hasn't been studied specifically in elderly people. But the individual components don't need a dose adjustment in the elderly, so it's unlikely that the combination would need one either.
Storage
Keep in a cool, dry place, below 30 degree C.
Drug Interactions
Common questions about Maxpro Hp 20 mg+1000 mg+500 mg
What is Maxpro Hp 20 mg+1000 mg+500 mg Tablet?
Maxpro Hp 20 mg+1000 mg+500 mg Tablet is a medicine that contains Esomeprazole + Amoxicillin + Clarithromycin. It is made by Renata PLC. It belongs to the Anti H. pylori drugs group of medicines.
What is Maxpro Hp used for?
Esomeprazole + Amoxicillin + Clarithromycin is used to clear (eradicate) H. pylori infection in people with active chronic gastric ulcers, duodenal ulcers and gastric ulcers.
What are the side effects of Maxpro Hp?
Most people tolerate H. pylori eradication therapy with Esomeprazole, Amoxicillin and Clarithromycin well.
Can I take Maxpro Hp during pregnancy or while breastfeeding?
Esomeprazole + Amoxicillin + Clarithromycin should be given to a pregnant woman only when its use is considered essential. For breastfeeding, nobody has established yet whether this combination is safe for the infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Maxpro Hp?
Keep in a cool, dry place, below 30 degree C.
Can I take other medicines with Maxpro Hp?
Some medicines can interact with Esomeprazole + Amoxicillin + Clarithromycin, for example: Cyclosporine, Prednisolone, Carbamazepine, Phenytoin, Lovastatin, Theophylline. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Maxpro Hp?
Maxpro Hp is a prescription (Rx) medicine. Take it as your doctor advises.