Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Indications

Hypertension Heart Failure Myocardial Infarction

Aldonist is used to treat hypertension (high blood pressure), and to manage congestive heart failure following an acute myocardial infarction (heart attack).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Eplerenone works by blocking aldosterone from attaching to its receptor in the body. It binds to the mineralocorticoid receptor, so aldosterone cannot act on it. Aldosterone is a hormone in the renin-angiotensin-aldosterone system (RAAS), and it is made mainly in the adrenal gland. Several things control how much is produced, including angiotensin II and other non-RAAS factors such as adrenocorticotropic hormone and potassium.

Aldosterone attaches to mineralocorticoid receptors in two kinds of tissue. One kind is epithelial tissue, such as the kidney. The other is nonepithelial tissue, such as the heart, blood vessels and brain. In these places it raises blood pressure by causing the body to hold on to sodium, and it may also work through other mechanisms.

Eplerenone causes plasma renin and serum aldosterone to stay raised over time. This happens because aldosterone normally acts as a brake on renin release, and eplerenone takes that brake off. The higher renin activity and aldosterone levels that follow do not cancel out the effect of eplerenone.

Pregnancy & Breastfeeding

Pregnancy: There are no adequate, well-controlled studies of Eplerenone use in pregnant women, so it should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to the unborn child.

Breastfeeding: It is not known whether Eplerenone passes into human breast milk after it is taken by mouth. Since many medicines do pass into breast milk and the possible effects on a nursing infant are not known, a decision should be made to either stop breastfeeding or stop the medicine, weighing how important it is for the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Congestive heart failure following a recent heart attack: The usual dose of Eplerenone for this condition is 50 mg once daily. Treatment is generally started at 25 mg once daily, with the dose increased to the 50 mg once-daily target within about 4 weeks, as the patient is able to tolerate it. Eplerenone can be taken with or without food. Hypertension: Eplerenone may be used on its own or together with other blood pressure lowering medicines. The usual starting dose for hypertension is 50 mg once daily. If blood pressure is not adequately controlled on 50 mg once daily, the dose may be increased to 50 mg twice daily. Doses higher than this are not advised, since they do not lower blood pressure any further than 100 mg a day and carry a greater risk of high potassium levels in the blood. Use in children: The safety and effectiveness of Eplerenone in pediatric patients have not been established. Use in the elderly: No differences in overall effectiveness or safety were seen in geriatric patients compared with younger adults.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.