Eltrombopag Olamine

Adults: Eltrombopag tablets are taken by mouth, either without food or with a meal that is low in calcium (<50 mg). For persistent or chronic immune thrombocytopenia, use the lowest dose that gets the platelet count to 50x109/L or above and keeps it there, as needed to reduce the risk of bleeding. Do not exceed 75 mg daily. Adults and pediatric patients 6 years and older with ITP start on 50 mg once daily, except patients of Asian ancestry or those with mild to severe hepatic impairment. Patients of Asian ancestry with ITP start on a reduced dose of 25 mg once daily. Patients with ITP and mild, moderate or severe hepatic impairment also start on a reduced dose of 25 mg once daily. For patients of Asian ancestry with ITP and hepatic impairment, consider starting at a reduced dose of 12.5 mg once daily. Pediatric patients with ITP aged 1 to 5 years start at 25 mg once daily. For thrombocytopenia associated with chronic hepatitis C, the starting dose is 25 mg once daily. Adjust it in 25 mg increments every 2 weeks as necessary to reach the target platelet count required to begin antiviral therapy, and do not exceed 100 mg daily. In first line severe aplastic anemia, start once daily at 2.5 mg/kg for pediatric patients aged 2 to 5 years old, 75 mg for pediatric patients aged 6 to 11 years old, or 150 mg for patients aged 12 years and older. This runs for 6 months, together with standard immunosuppressive therapy. For patients of Asian ancestry or those with mild, moderate or severe hepatic impairment, decrease the initial dose by 50%. The dose regimen is then modified based on platelet counts, ALT or AST elevations and thromboembolic events. In refractory severe aplastic anemia, start at 50 mg once daily. A hematologic response needs dose titration, generally up to 150 mg, and may take up to 16 weeks after starting. For patients of Asian ancestry or those with mild, moderate, or severe hepatic impairment, start at a reduced dose of 25 mg once daily. Adjust the dose in 50 mg increments every 2 weeks as necessary to reach a target platelet count of 50 x 109/L or above. Do not exceed 150 mg per day.