Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 2 months ago

Doxorubicin Hydrochloride

Cytotoxic Chemotherapy Prescription
Check interactions
🌐 বাংলায় দেখুন

Indications

Cancer

Doxorubicin SDZ SDZ is indicated as part of multi-drug adjuvant chemotherapy for women whose axillary lymph nodes are involved, given after surgical removal of the primary breast cancer. It is also used to treat acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms' tumor, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma and metastatic bronchogenic carcinoma.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Doxorubicin hydrochloride is a cytotoxic anthracycline that inhibits topoisomerase II. The cytotoxic effect of Doxorubicin HCl on malignant cells, along with its toxic effects on various organs, is thought to stem from the drug's ability to intercalate between nucleotide bases and bind to cell membrane lipids. This intercalation blocks nucleotide replication and interferes with the action of DNA and RNA polymerases. The interaction of Doxorubicin with topoisomerase II to form DNA cleavable complexes appears to be an important mechanism behind the cytocidal activity of Doxorubicin HCl.

Pregnancy & Breastfeeding

Doxorubicin HCl is Pregnancy Category D, which means it can cause fetal harm when given to a pregnant woman. If it is used during pregnancy, or if a patient becomes pregnant while taking Doxorubicin HCl, she should be told about the possible danger to the fetus. Women who could become pregnant should be advised to use highly effective contraception while on treatment and for 6 months after it ends.

There is evidence that Doxorubicinbe excreted in human milk. Because nursing infants could suffer serious adverse reactions from Doxorubicin HCl, a decision has to be made either to stop nursing or to stop the drug, taking into account how important the drug is for the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: When Doxorubicin HCl is used as a single agent, the dose is 60 to 75 mg/m2 given intravenously every 21 days. In combination therapy, the dose is 40 to 75 mg/m2 given intravenously every 21 to 28 days. Doxorubicin HCl should be discontinued in patients who develop signs or symptoms of cardiomyopathy, and the dose should be reduced in patients with hepatic impairment. As an intravenous injection, Doxorubicin HCl is given through a central intravenous line, or through a secure and free-flowing peripheral venous line containing 0.9% Sodium Chloride Injection, USP, 0.45% Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP. The injection runs over 3 to 10 minutes. If erythematous streaking appears along the vein proximal to the site of infusion, or if facial flushing occurs, the rate of administration should be decreased. As an intravenous infusion, Doxorubicin HCl is given only through a central catheter. Management of Suspected Extravasation: Doxorubicin HCl should be discontinued if the patient feels a burning or stinging sensation, or if there is other evidence of perivenous infiltration or extravasation. Confirmed or suspected extravasation is managed as follows. The needle should be left in place until attempts have been made to aspirate the extravasated fluid. The line should not be flushed, and pressure should not be applied to the site. Ice should be applied to the site intermittently for 15 min, 4 times a day, for 3 days. If the extravasation is in an extremity, the extremity should be elevated. In adults, administration of dexrazoxane should be considered. Incompatibility with Other Drugs: Doxorubicin hydrochloride should not be admixed with other drugs. A precipitate may form if Doxorubicin HCl is mixed with heparin or fluorouracil. Contact with alkaline solutions should be avoided, as these can lead to hydrolysis of Doxorubicin hydrochloride.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.