Indications
Doxophylline (DFN) is used to relieve bronchial asthma, bronchospasm, chronic obstructive pulmonary disease (COPD), and other pulmonary conditions involving spasm of the bronchial airways.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Doxophylline is a newer type of bronchodilator. Its structure differs from Theophylline's by the presence of a dioxolane group at position 7. It works by selectively blocking the phosphodiesterase 4 enzyme, which relaxes the smooth muscle lining the airways. Unlike Theophylline, however, Doxophylline binds much less strongly to adenosine A1 and A2 receptors, and this is thought to be why it tends to be better tolerated. It has also been shown to suppress platelet-activating factor (PAF) and reduce the production of leukotrienes.
Pregnancy & Breastfeeding
In animal tests, the active ingredient of Doxophylline did not interfere with growth before or after birth. There isn't enough clinical evidence yet about how the medicine affects pregnant women, so its use during pregnancy should be weighed carefully case by case, looking at the risk against the benefit.
Doxophylline is contraindicated during breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.