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Domperidone Maleate

Motility Stimulants Prescription
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Indications

Domperidone Maleate is used for dyspeptic symptom complex, which is often linked with delayed gastric emptying, gastroesophageal reflux and esophagitis. The symptoms include an epigastric sense of fullness, a feeling of abdominal distension, upper abdominal pain, eructation, flatulence, early satiety, nausea and vomiting, and heartburn with or without regurgitations of gastric contents in the mouth. It is also used for non-ulcer dyspepsia, and for acute nausea and vomiting of functional, organic, infectious or dietetic origin, or nausea and vomiting induced by radiotherapy, by drug therapy or in migraine. In Parkinson's disease, it is used for nausea and vomiting induced by dopamine agonists. In radiological studies, it speeds barium transit in follow-through studies.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Domperidone is a dopamine antagonist. It mainly blocks the dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and in the stomach. Its gastroprokinetic action comes from this blocking effect on the dopamine receptors that influence how the gastrointestinal tract moves.

Domperidone doesn't cross the blood-brain barrier well, so it has almost no effect on the dopaminergic receptors in the brain. For this reason, psychotropic and neurologic side effects are excluded.

Domperidone restores normal motility and tone of the upper gastrointestinal tract, helps gastric emptying, increases antral and duodenal peristalsis and regulates contraction of the pylorus. It also increases esophageal peristalsis and lower esophageal sphincter pressure, and so prevents regurgitation of gastric content.

Pregnancy & Breastfeeding

Domperidone did not cause teratogenic effects in animals given doses up to 160 mg/kg/day. Even so, like most medicines, domperidone should be used in the first trimester of pregnancy only if the expected benefit justifies it. So far there is no evidence that it raises the risk of malformations in humans.

In lactating rats, the drug passes into breast milk. In women, the domperidone concentration in breast milk is 4 times lower than the matching concentration in plasma. It is not known whether this is harmful to a newborn. For that reason, nursing is not recommended for mothers who are taking domperidone, unless the expected benefits outweigh any potential risk.

Effects on ability to drive and use machines: Domperidone does not affect mental alertness.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Take Domperidone 15 to 30 minutes before meals and, if needed, again before going to bed. The usual oral dose is as follows. Adults: 10 to 20 mg (1 to 2 tablets or 10 to 20 ml suspension), every 6 to 8 hours daily. The maximum dose of Domperidone is 80 mg daily. Children: 2 to 4 ml suspension per 10 kg body weight, or 0.4 to 0.8 ml paediatric drops per 10 kg body weight, every 6 to 8 hours daily. For dyspeptic symptoms, adults take 10 to 20 mg (1 to 2 tablets or 10 to 20 ml suspension) every 6 to 8 hours daily. Children take 0.2 to 0.4 mg/kg (2 to 4 ml suspension per 10 kg or 0.4 to 0.8 ml paediatric drops per 10 kg) body weight, every 6 to 8 hours daily. In acute and sub-acute conditions (mainly acute nausea and vomiting), adults take 20 mg (2 tablets or 20 ml suspension) every 6 to 8 hours daily. Children take 0.2 to 0.4 mg/kg (2 to 4 ml suspension per 10 kg or 0.4 to 0.8 ml paediatric drops per 10 kg) body weight, every 6 to 8 hours daily. In acute nausea and vomiting, the maximum period of treatment is 12 weeks. By rectum, as suppositories: adults (including elderly) use 30 to 60 mg every 4 to 8 hours. For children, the maximum daily rectal dose is 30 mg for those weighing 10 to 25 kg. The dose may be divided through the day if necessary. The maximum period of treatment is 12 weeks.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.