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Indications & Uses
Domperidone Maleate is used for dyspeptic symptom complex, which is often linked with delayed gastric emptying, gastroesophageal reflux and esophagitis. The symptoms include an epigastric sense of fullness, a feeling of abdominal distension, upper abdominal pain, eructation, flatulence, early satiety, nausea and vomiting, and heartburn with or without regurgitations of gastric contents in the mouth. It is also used for non-ulcer dyspepsia, and for acute nausea and vomiting of functional, organic, infectious or dietetic origin, or nausea and vomiting induced by radiotherapy, by drug therapy or in migraine. In Parkinson's disease, it is used for nausea and vomiting induced by dopamine agonists. In radiological studies, it speeds barium transit in follow-through studies.
Pharmacology
Domperidone is a dopamine antagonist. It mainly blocks the dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and in the stomach. Its gastroprokinetic action comes from this blocking effect on the dopamine receptors that influence how the gastrointestinal tract moves.
Domperidone doesn't cross the blood-brain barrier well, so it has almost no effect on the dopaminergic receptors in the brain. For this reason, psychotropic and neurologic side effects are excluded.
Domperidone restores normal motility and tone of the upper gastrointestinal tract, helps gastric emptying, increases antral and duodenal peristalsis and regulates contraction of the pylorus. It also increases esophageal peristalsis and lower esophageal sphincter pressure, and so prevents regurgitation of gastric content.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take Domperidone 15 to 30 minutes before meals and, if needed, again before going to bed. The usual oral dose is as follows.
Adults: 10 to 20 mg (1 to 2 tablets or 10 to 20 ml suspension), every 6 to 8 hours daily. The maximum dose of Domperidone is 80 mg daily.
Children: 2 to 4 ml suspension per 10 kg body weight, or 0.4 to 0.8 ml paediatric drops per 10 kg body weight, every 6 to 8 hours daily.
For dyspeptic symptoms, adults take 10 to 20 mg (1 to 2 tablets or 10 to 20 ml suspension) every 6 to 8 hours daily. Children take 0.2 to 0.4 mg/kg (2 to 4 ml suspension per 10 kg or 0.4 to 0.8 ml paediatric drops per 10 kg) body weight, every 6 to 8 hours daily.
In acute and sub-acute conditions (mainly acute nausea and vomiting), adults take 20 mg (2 tablets or 20 ml suspension) every 6 to 8 hours daily. Children take 0.2 to 0.4 mg/kg (2 to 4 ml suspension per 10 kg or 0.4 to 0.8 ml paediatric drops per 10 kg) body weight, every 6 to 8 hours daily. In acute nausea and vomiting, the maximum period of treatment is 12 weeks.
By rectum, as suppositories: adults (including elderly) use 30 to 60 mg every 4 to 8 hours. For children, the maximum daily rectal dose is 30 mg for those weighing 10 to 25 kg. The dose may be divided through the day if necessary. The maximum period of treatment is 12 weeks.
Side Effects
Side effects with domperidone maleate are rare. Some short-lived intestinal cramps have been reported, but only in exceptional cases. Extrapyramidal phenomena are rare in young children and exceptional in adults, and they reverse completely and on their own as soon as the treatment is stopped. The pituitary gland sits outside the blood-brain barrier, so domperidone may raise the plasma prolactin level. In rare cases this hyperprolactinaemia can lead to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. Where the blood-brain barrier is immature (as in infants) or impaired, neurological side effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.
Cautions & Contraindications
Warnings & Precautions
Domperidone Maleate needs great care in children. Young children may be more likely to have extra-pyramidal reactions, because their blood-brain barrier is not fully developed yet. Domperidone is also broken down heavily in the liver, so it should be used with caution in patients whose liver function is impaired.
Contraindications
Domperidone must not be given to anyone with a known hypersensitivity to it, and it must not be given to neonates. It should also not be used where stimulating the gut could be dangerous, such as gastrointestinal hemorrhage, mechanical obstruction or perforation. Domperidone is also contraindicated in patients with a prolactin-releasing pituitary tumor (prolactinoma).
Pregnancy & Breastfeeding
Domperidone did not cause teratogenic effects in animals given doses up to 160 mg/kg/day. Even so, like most medicines, domperidone should be used in the first trimester of pregnancy only if the expected benefit justifies it. So far there is no evidence that it raises the risk of malformations in humans.
In lactating rats, the drug passes into breast milk. In women, the domperidone concentration in breast milk is 4 times lower than the matching concentration in plasma. It is not known whether this is harmful to a newborn. For that reason, nursing is not recommended for mothers who are taking domperidone, unless the expected benefits outweigh any potential risk.
Effects on ability to drive and use machines: Domperidone does not affect mental alertness.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in infants: The metabolic and blood-brain barrier functions are not fully developed during the first months of life, so any drug should be given to infants with great caution and under close medical supervision. Domperidone usually causes no neurological side effects, mainly because very little of it crosses the blood-brain barrier. For that reason, such effects can't be totally excluded in infants under 1 year of age. Use in liver disorders: Domperidone is highly metabolised in the liver, so it should be used with caution in patients with hepatic impairment. Use in kidney disorders: In patients with severe renal insufficiency (serum creatinine >6 mg/100ml, i.e. >O.6 mmol/I), the elimination half-life of domperidone increased from 7.4 to 20.8 hours, but plasma drug levels were lower than in healthy volunteers. Very little unchanged drug is excreted via the kidneys, so the dose of a single acute administration is unlikely to need adjustment in renal insufficiency. On repeated administration, however, the dosing frequency should be reduced to once or twice daily, depending on the severity of the impairment, and the dose may need to be reduced. Generally, patients on prolonged therapy should be reviewed regularly.
Overdose
An overdose of Domperidone Maleate may cause drowsiness, disorientation and extrapyramidal reactions, and these reactions are seen especially in children. If an overdose happens, activated charcoal is recommended and the patient should be watched closely. Anticholinergic drugs, antiparkinson drugs, or antihistamines that have anticholinergic properties may help control the extrapyramidal reactions.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Domperidone Maleate below 30°C. It should be protected from light and moisture. Keep it out of children's reach.
Drug Interactions
Common questions about Dedom 5 mg/5 ml
What is Dedom 5 mg/5 ml Oral Suspension?
Dedom 5 mg/5 ml Oral Suspension is a medicine that contains Domperidone Maleate. It is made by Decent Pharma Laboratories Ltd. It belongs to the Motility Stimulants group of medicines.
What is Dedom used for?
Domperidone Maleate is used for dyspeptic symptom complex, which is often linked with delayed gastric emptying, gastroesophageal reflux and esophagitis. The symptoms include an epigastric sense of fullness, a feeling of abdominal distension, upper abdominal pain, eructation, flatulence, early satiety, nausea and vomiting, and heartburn with or without regurgitations of gastric contents in the mouth.
What are the side effects of Dedom?
Side effects with domperidone maleate are rare. Some short-lived intestinal cramps have been reported, but only in exceptional cases.
Can I take Dedom during pregnancy or while breastfeeding?
Domperidone did not cause teratogenic effects in animals given doses up to 160 mg/kg/day. Even so, like most medicines, domperidone should be used in the first trimester of pregnancy only if the expected benefit justifies it. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dedom?
An overdose of Domperidone Maleate may cause drowsiness, disorientation and extrapyramidal reactions, and these reactions are seen especially in children. If an overdose happens, activated charcoal is recommended and the patient should be watched closely. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dedom?
Store Domperidone Maleate below 30°C. It should be protected from light and moisture.
Do I need a prescription for Dedom?
Dedom is a prescription (Rx) medicine. Take it as your doctor advises.