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Community data Updated 23 hours ago

Dobutamine Hydrochloride

Inotropic-sympathomimetics Prescription
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Indications

Edema

Dobutamine Hydrochloride is used when a patient needs inotropic support (help to make the heart pump harder) and the heart isn't sending out enough blood to meet what the body needs. This is the hypoperfusion state, where tissues don't get enough blood flow. It is also used when inotropic support is needed because ventricular filling pressures have risen abnormally, which puts the patient at risk of pulmonary congestion and oedema.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Dobutamine Hydrochloride is a direct-acting inotropic agent. Its main action comes from stimulating adrenergic receptors in the heart. The chronotropic, hypertensive, arrhythmogenic and vasodilatory effects it produces are comparatively mild.

Unlike dopamine, Dobutamine Hydrochloride does not release norepinephrine, so its actions don't depend on norepinephrine stores in the heart. In humans it increases stroke volume and cardiac output. It also decreases ventricular filling pressure and total systemic and pulmonary vascular resistances.

Pregnancy & Breastfeeding

Dobutamine Hydrochloride hasn't been studied in adequate, well-controlled trials in pregnant women. So it should not be used during pregnancy unless the possible benefit outweighs the possible risk to the foetus.

It isn't known whether this medicine passes into human milk. Many medicines do, so caution is needed when Dobutamine Hydrochloride is given to a nursing woman. If a mother needs dobutamine treatment, she should stop breastfeeding for as long as the treatment lasts.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dobutamine Hydrochloride has a short half-life, so it must be given as a continuous intravenous infusion. Once a constant rate infusion is started, or the rate is changed, the plasma dobutamine concentration reaches a steady state within about 10 minutes. Because of this, loading doses and bolus injections aren't necessary and are not recommended. Recommended Dosage In most patients, the infusion rate needed to increase cardiac output has ranged from 2.5 to 10 mcg/kg/min. Doses up to 20 mcg/kg/min are often required for adequate haemodynamic improvement. On rare occasions, rates up to 40 mcg/kg/min have been reported. The rate and the duration of therapy should be adjusted according to the patient's response. The indicators are haemodynamic parameters such as heart rate and rhythm, arterial pressure, and, whenever possible, cardiac output, measurements of ventricular filling pressures and signs of pulmonary congestion. Concentrations up to 5,000 mg/L have been given to humans. The final volume should be decided by the patient's fluid requirements. Rather than stopping Dobutamine Hydrochloride suddenly, it is often advisable to lower the dose gradually. Rates of Infusion Based on Concentration of Dobutamine Hydrochloride The fluid infusion rate needed to deliver a specific dose depends on the concentration of Dobutamine Hydrochloride in the infusate. The table below is a guideline for the infusion rates (mL/kg/min) needed with 3 frequently used concentrations, 250, 500 and 1000 mg/L. Dobutamine Injection was diluted to 250 micrograms/mL and 500 micrograms/mL with 0.9% Sodium Chloride Injection and 5% Glucose Injection. At these dilutions it was found to be stable for 24 hours at room temperature and in the presence of fluorescent light.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.