Dobumin

Dobutamine Hydrochloride has a short half-life, so it must be given as a continuous intravenous infusion. Once a constant rate infusion is started, or the rate is changed, the plasma dobutamine concentration reaches a steady state within about 10 minutes. Because of this, loading doses and bolus injections aren't necessary and are not recommended.

Recommended Dosage

In most patients, the infusion rate needed to increase cardiac output has ranged from 2.5 to 10 mcg/kg/min. Doses up to 20 mcg/kg/min are often required for adequate haemodynamic improvement. On rare occasions, rates up to 40 mcg/kg/min have been reported. The rate and the duration of therapy should be adjusted according to the patient's response. The indicators are haemodynamic parameters such as heart rate and rhythm, arterial pressure, and, whenever possible, cardiac output, measurements of ventricular filling pressures and signs of pulmonary congestion.

Concentrations up to 5,000 mg/L have been given to humans. The final volume should be decided by the patient's fluid requirements. Rather than stopping Dobutamine Hydrochloride suddenly, it is often advisable to lower the dose gradually.

Rates of Infusion Based on Concentration of Dobutamine Hydrochloride

The fluid infusion rate needed to deliver a specific dose depends on the concentration of Dobutamine Hydrochloride in the infusate. The table below is a guideline for the infusion rates (mL/kg/min) needed with 3 frequently used concentrations, 250, 500 and 1000 mg/L.

Dobutamine Injection was diluted to 250 micrograms/mL and 500 micrograms/mL with 0.9% Sodium Chloride Injection and 5% Glucose Injection. At these dilutions it was found to be stable for 24 hours at room temperature and in the presence of fluorescent light.