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Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Centoxin is indicated for:
Pharmacology
Digoxin is a cardiac glycoside used mainly in the treatment of atrial fibrillation and heart failure. Its main effects are to strengthen the force of the heart's contractions (a positive inotropic effect) and to slow conduction through the heart, particularly through the atrioventricular node. Digoxin also acts directly on the smooth muscle of blood vessels, and produces indirect effects mainly through the autonomic nervous system, especially by increasing vagal activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
By mouth, the dose depends on how quickly the heart needs to be brought under control. For rapid digitalisation, the usual total is 1 to 1.5 mg, given in divided doses over 24 hours. When there is less urgency, the dose is 250 to 500 micrograms a day, and the higher dose may be split up across the day.
For maintenance, the daily dose is 62.5 to 500 micrograms, and the higher doses may be divided. The right figure depends on kidney function and, in atrial fibrillation, on the heart rate response. The usual range is 125 to 250 micrograms a day, and the lower dose may be divided. Again, kidney function and the heart rate response guide the choice. In older people, a dose at the lower end of this range may be appropriate.
Side Effects
Side effects are usually linked to excessive dosage and may include loss of appetite, nausea, vomiting, diarrhoea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block and intestinal ischaemia. Gynaecomastia may occur with long-term use, and thrombocytopenia has been reported. Centoxin can be safely used in pregnancy.
Cautions & Contraindications
Contraindications
Digoxin should not be used in ventricular fibrillation, or in people allergic to digoxin or any other digitalis preparation.
Pregnancy & Breastfeeding
Digoxin passes into breast milk, but at levels lower than those in the mother's blood, so it poses no risk to a breastfeeding infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Neonates: Digoxin can be used in neonates.
Children: Digoxin can be used in children.
The elderly: Older people need a lower maintenance dose of Digoxin than younger adults. This is partly because their kidney function is reduced, and partly because their tissues are more sensitive to the effects of digitalis.
Storage
Keep Digoxin in a cool, dry place, and keep it out of the reach of children.
Drug Interactions
Common questions about Centoxin 0.25 mg
What is Centoxin 0.25 mg Tablet?
Centoxin 0.25 mg Tablet is a medicine that contains Digoxin. It is made by Opsonin Pharma Limited. It belongs to the Positive Inotropic drugs group of medicines.
What is Centoxin used for?
Centoxin is used for: Heart Failure, Cardiac Arrhythmia.
What are the side effects of Centoxin?
Side effects are usually linked to excessive dosage and may include loss of appetite, nausea, vomiting, diarrhoea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block and intestinal ischaemia. Gynaecomastia may occur with long-term use, and thrombocytopenia has been reported.
Can I take Centoxin during pregnancy or while breastfeeding?
Digoxin passes into breast milk, but at levels lower than those in the mother's blood, so it poses no risk to a breastfeeding infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Centoxin?
Keep Digoxin in a cool, dry place, and keep it out of the reach of children.
Can I take other medicines with Centoxin?
Some medicines can interact with Digoxin, for example: Calcium Carbonate, Conventional Calcium + Vitamin D3, Ticagrelor, Naproxen Sodium + Esomeprazole Magnesium, Vildagliptin, Atorvastatin Calcium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Centoxin is already among the lowest-priced brands of Digoxin at this strength.
Do I need a prescription for Centoxin?
Centoxin is a prescription (Rx) medicine. Take it as your doctor advises.