Indications
Remazin treats filariasis (including lymphatic filariasis), pulmonary eosinophilia, loiasis, and toxocariasis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Mechanism of action: diethylcarbamazine appears to work by sensitising the microfilariae to phagocytosis. One study found that its activity against Brugia malayi microfilariae depends on inducible nitric-oxide synthase and the cyclooxygenase pathway. This confirmed that the arachidonic acid metabolic pathway plays an important part in the drug's mechanism of action in vivo, and showed that, besides acting on the 5-lipoxygenase pathway, it also targets the cyclooxygenase pathway and COX-1.
Pregnancy & Breastfeeding
Diethylcarbamazine Citrate is in Pregnancy Category X. This means studies in animals or humans have shown fetal abnormalities, or there is positive evidence of risk to the human fetus from adverse reaction reports made during investigational use or after the medicine was marketed. For pregnant women, the risks of taking it clearly outweigh any possible benefit, so it should not be used during pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.