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Other brands with the same active ingredient
These brands contain the same active ingredient (Diethylcarbamazine Citrate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Remazin treats filariasis (including lymphatic filariasis), pulmonary eosinophilia, loiasis, and toxocariasis.
Pharmacology
Mechanism of action: diethylcarbamazine appears to work by sensitising the microfilariae to phagocytosis. One study found that its activity against Brugia malayi microfilariae depends on inducible nitric-oxide synthase and the cyclooxygenase pathway. This confirmed that the arachidonic acid metabolic pathway plays an important part in the drug's mechanism of action in vivo, and showed that, besides acting on the 5-lipoxygenase pathway, it also targets the cyclooxygenase pathway and COX-1.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Initial dose: 1 mg/kg/day, increased gradually to 6 mg/kg/day over 3 days, then continued for 3 weeks. For prevention of loiasis: 300 mg once weekly.
Side Effects
Common side effects include fever, headache, vomiting, dizziness, drowsiness, nausea, and chills. Potentially Fatal: Severe hypersensitivity reactions may occur, especially during treatment of onchocerciasis, where a rare Mazzotti reaction marked by rash, itching, headache, muscle and joint pain, rapid heartbeat, and a drop in blood pressure on standing may begin within 2 hours of taking the drug. Encephalitis and retinal haemorrhage may also occur.
Cautions & Contraindications
Warnings & Precautions
Not recommended for patients in poor health. Lactation: not known whether it passes into breast milk.
Contraindications
Don't give Diethylcarbamazine Citrate in pregnancy, to anyone hypersensitive to it, or during lactation. It is also unsuitable for infants, the elderly or debilitated patients, and for people with impaired renal function or cardiac disease.
Pregnancy & Breastfeeding
Diethylcarbamazine Citrate is in Pregnancy Category X. This means studies in animals or humans have shown fetal abnormalities, or there is positive evidence of risk to the human fetus from adverse reaction reports made during investigational use or after the medicine was marketed. For pregnant women, the risks of taking it clearly outweigh any possible benefit, so it should not be used during pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Common questions about Notezine 50 mg
What is Notezine 50 mg Tablet?
Notezine 50 mg Tablet is a medicine that contains Diethylcarbamazine Citrate. It is made by Synovia Pharma PLC. It belongs to the Other Anti-protozoals group of medicines.
What is Notezine used for?
Remazin treats filariasis (including lymphatic filariasis), pulmonary eosinophilia, loiasis, and toxocariasis.
What are the side effects of Notezine?
Common side effects include fever, headache, vomiting, dizziness, drowsiness, nausea, and chills. Potentially Fatal: Severe hypersensitivity reactions may occur, especially during treatment of onchocerciasis, where a rare Mazzotti reaction marked by rash, itching, headache, muscle and joint pain, rapid heartbeat, and a drop in blood pressure on standing may begin within 2 hours of taking the drug.
Can I take Notezine during pregnancy or while breastfeeding?
Diethylcarbamazine Citrate is in Pregnancy Category X. This means studies in animals or humans have shown fetal abnormalities, or there is positive evidence of risk to the human fetus from adverse reaction reports made during investigational use or after the medicine was marketed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Do I need a prescription for Notezine?
Notezine is a prescription (Rx) medicine. Take it as your doctor advises.