Dexamethasone + Neomycin Sulphate + Polymyxin B Sulphate

Dexamethasone is a corticosteroid. It suppresses the inflammatory response to many different agents, and it probably delays or slows healing. A corticosteroid may also weaken the body's defence against infection, so an antimicrobial medicine may be used alongside it when this effect is considered clinically significant in a particular case. In this combination of dexamethasone, neomycin sulphate and polymyxin B sulphate, the anti-infective part is there to act against the specific organisms that are susceptible to it.

Neomycin sulphate is considered active against these microorganisms: Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus Viridans, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes and Haemophilus influenzae. Polymyxin B sulphate is considered active against these: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Koch-Weeks bacillus.

Once a decision has been made to give both a corticosteroid and an antimicrobial, using them together in one preparation has some advantages. Patients are more likely to follow the treatment, and it is more convenient for them. The appropriate dose of both drugs is assured, and so is the compatibility of the ingredients when both types of drug are in the same formulation. In particular, the correct volume of the drug is delivered and retained.