Indications
Dexamethasone + Levofloxacin ophthalmic solution is used in adults after cataract surgery. It helps prevent and treat inflammation, and it also helps prevent infection linked to the surgery.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Levofloxacin is a synthetic third-generation fluoroquinolone antibacterial. It blocks the supercoiling activity of bacterial DNA gyrase, and this halts DNA replication. It is the active L-isomer of ofloxacin and inhibits two bacterial type II topoisomerases, DNA gyrase and topoisomerase IV. In Gram-negative bacteria levofloxacin mainly targets DNA gyrase, while in Gram-positive bacteria it mainly targets topoisomerase IV. Dexamethasone phosphate acts in a different way. It inhibits phospholipase A2, the first step in prostaglandin synthesis, and it also inhibits the chemotactic infiltration of neutrophils into the site of inflammation. Its anti-inflammatory activity is 30 times greater than that of hydrocortisone, and its overall therapeutic effectiveness is 8 to 10 times greater. Like other glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative.
Pregnancy & Breastfeeding
There is little or no data on the use of Dexamethasone and Levofloxacin in pregnant women. Corticosteroids cross the placenta. If a corticosteroid is used for a long time or repeatedly during pregnancy, it has been linked with a higher risk of lower birth weight, and with high blood pressure, vascular disorders and insulin resistance in adulthood.
Dexamethasone and Levofloxacin are excreted into human milk. No data is available to show whether relevant amounts of Dexamethasone or Levofloxacin pass into breast milk, or whether those amounts can produce clinical effects in the infant. Caution should be exercised when the combination is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.