Indications & Uses
Trevox-D is indicated for:
Pharmacology
Levofloxacin is a synthetic third-generation fluoroquinolone antibacterial. It blocks the supercoiling activity of bacterial DNA gyrase, and this halts DNA replication. It is the active L-isomer of ofloxacin and inhibits two bacterial type II topoisomerases, DNA gyrase and topoisomerase IV. In Gram-negative bacteria levofloxacin mainly targets DNA gyrase, while in Gram-positive bacteria it mainly targets topoisomerase IV. Dexamethasone phosphate acts in a different way. It inhibits phospholipase A2, the first step in prostaglandin synthesis, and it also inhibits the chemotactic infiltration of neutrophils into the site of inflammation. Its anti-inflammatory activity is 30 times greater than that of hydrocortisone, and its overall therapeutic effectiveness is 8 to 10 times greater. Like other glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults use one drop of Dexamethasone + Levofloxacin in the conjunctival sac after surgery. This is repeated every 6 hours for 7 days.
The combination is not recommended for children and adolescents below 18 years, because there isn't enough data on its safety and efficacy in this age group.
Side Effects
The side effects people report most often with Dexamethasone + Levofloxacin are not serious ones: eye irritation, ocular hypertension and headache. The pressure inside the eye (intra-ocular pressure, IOP) may rise, and glaucoma can develop. People with diabetes are also more likely to get subcapsular cataracts after using a topical steroid for a long time. Some reactions can affect the cornea too, such as thinning of the cornea and, in some cases, perforation of the cornea.
Cautions & Contraindications
Warnings & Precautions
This eye drop, the dexamethasone and levofloxacin combination, is for use in the eye only. If you use it for a long time, bacteria can become resistant to the antibiotic, and organisms that the antibiotic can't kill, fungi included, may then overgrow. If an infection develops, stop the treatment and switch to another therapy. Long-term use of topical ophthalmic corticosteroids can cause ocular hypertension or glaucoma. This is unlikely when the drop is used only for the recommended treatment period of 7 days.
Contraindications
Don't use Dexamethasone + Levofloxacin if you are hypersensitive to any component of the formulation. It is also contraindicated in herpes simplex keratitis, varicella and other viral diseases of the cornea and conjunctiva, in mycobacterial infections of the eye, and in fungal diseases of the ocular structures.
Pregnancy & Breastfeeding
There is little or no data on the use of Dexamethasone and Levofloxacin in pregnant women. Corticosteroids cross the placenta. If a corticosteroid is used for a long time or repeatedly during pregnancy, it has been linked with a higher risk of lower birth weight, and with high blood pressure, vascular disorders and insulin resistance in adulthood.
Dexamethasone and Levofloxacin are excreted into human milk. No data is available to show whether relevant amounts of Dexamethasone or Levofloxacin pass into breast milk, or whether those amounts can produce clinical effects in the infant. Caution should be exercised when the combination is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Dexamethasone + Levofloxacin from local use or from swallowing it by accident is not likely. Even if an overdose did happen, it is unlikely to threaten life.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Dexamethasone + Levofloxacin below 30°C, in a dry place and away from light. Keep it out of the reach of children. Don't touch the tip of the dropper bottle, because this may contaminate the product. Once you have opened the dropper for the first time, don't use the medicine after 1 month.
Drug Interactions
Common questions about Trevox-D 100 mg
What is Trevox-D 100 mg Eye Drops?
Trevox-D 100 mg Eye Drops is a medicine that contains Dexamethasone + Levofloxacin. It is made by Square Pharmaceuticals PLC, Gazipur.
What is Trevox-D used for?
Trevox-D is used for: Inflammation.
What are the side effects of Trevox-D?
The side effects people report most often with Dexamethasone + Levofloxacin are not serious ones: eye irritation, ocular hypertension and headache. The pressure inside the eye (intra-ocular pressure, IOP) may rise, and glaucoma can develop.
Can I take Trevox-D during pregnancy or while breastfeeding?
There is little or no data on the use of Dexamethasone and Levofloxacin in pregnant women. Corticosteroids cross the placenta. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Trevox-D?
An overdose of Dexamethasone + Levofloxacin from local use or from swallowing it by accident is not likely. Even if an overdose did happen, it is unlikely to threaten life. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Trevox-D?
Keep Dexamethasone + Levofloxacin below 30°C, in a dry place and away from light. Keep it out of the reach of children.
Can I take other medicines with Trevox-D?
Some medicines can interact with Dexamethasone + Levofloxacin, for example: Dexamethasone, Cimetidine, Levofloxacin, Bromfenac, Nepafenac, Ritonavir. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Trevox-D?
Trevox-D is a prescription (Rx) medicine. Take it as your doctor advises.