Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Dexamethasone + Chloramphenicol

Anti-infectives & antiseptics Prescription
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Indications

Bacterial Infection Otitis Media Conjunctivitis Inflammation

Eye: Dexamethasone + Chloramphenicol is used in acute purulent conjunctivitis, fresh inflammation of the superficial and deeper layers of the cornea, and corneal ulceration. It is also used in keratitis disciformis and the more deep-seated forms of post-herpetic keratitis, allergic conjunctivitis, allergic blepharitis, acute and chronic iritis, and chronic anterior uveitis. It is used as well for corneal injury from chemical radiation or thermal burns, or from penetration of foreign bodies. The combination is meant for steroid-responsive inflammatory eye conditions where a corticosteroid is indicated and where a bacterial infection, or a risk of one, exists. It can also be used for post-operative inflammation and for any other eye inflammation that comes with infection. Ear: Dexamethasone + Chloramphenicol is used in otitis externa, otitis media and chronic suppurative otitis media.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Dexamethasone is a glucocorticoid with anti-inflammatory and anti-allergic action. Applied topically, it is used to treat inflammatory conditions of the anterior segment of the eye. After oral administration it is absorbed rapidly, with a half-life of about 190 minutes. Enough can also be absorbed after it is applied to the skin or the eye to produce systemic effects.

Chloramphenicol is a broad spectrum bacteriostatic antibiotic, active against a wide variety of gram-negative and gram-positive organisms. It works by binding to bacterial ribosomes and stopping bacterial protein synthesis at an early stage.

Pregnancy & Breastfeeding

No adequate and well-controlled studies have been done in pregnant women. So Dexamethasone + Chloramphenicol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Take caution when Chloramphenicol and Dexamethasone ophthalmic solution is given to a nursing mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For eye infections, Dexamethasone + Chloramphenicol is used as follows. In bacterial conjunctivitis, put 1 to 2 drops into the conjunctival sac(s) every 2 hours for 2 days. For the next 5 days, use 1 or 2 drops every 4 hours while awake. In corneal ulcers, put 2 drops into the affected eye(s) every 15 minutes for the first 6 hours. For the rest of the first day, give 2 drops every 30 minutes. On the second day, use 2 drops in the affected eye(s) every hour. From day 3 to day 14, the dose is 2 drops in the affected eye(s) every 4 hours. If corneal re-epithelialization has not occurred by day 14, treatment may be continued. For ear infections of any kind, start with 2 to 3 drops every 2 to 3 hours. As the clinical signs improve, reduce how often the drops are given, and do it gradually. Take care not to stop the treatment too early.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.