Pricing
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Cloradex is indicated for:
Pharmacology
Dexamethasone is a glucocorticoid with anti-inflammatory and anti-allergic action. Applied topically, it is used to treat inflammatory conditions of the anterior segment of the eye. After oral administration it is absorbed rapidly, with a half-life of about 190 minutes. Enough can also be absorbed after it is applied to the skin or the eye to produce systemic effects.
Chloramphenicol is a broad spectrum bacteriostatic antibiotic, active against a wide variety of gram-negative and gram-positive organisms. It works by binding to bacterial ribosomes and stopping bacterial protein synthesis at an early stage.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For eye infections, Dexamethasone + Chloramphenicol is used as follows. In bacterial conjunctivitis, put 1 to 2 drops into the conjunctival sac(s) every 2 hours for 2 days. For the next 5 days, use 1 or 2 drops every 4 hours while awake.
In corneal ulcers, put 2 drops into the affected eye(s) every 15 minutes for the first 6 hours. For the rest of the first day, give 2 drops every 30 minutes. On the second day, use 2 drops in the affected eye(s) every hour. From day 3 to day 14, the dose is 2 drops in the affected eye(s) every 4 hours. If corneal re-epithelialization has not occurred by day 14, treatment may be continued.
For ear infections of any kind, start with 2 to 3 drops every 2 to 3 hours. As the clinical signs improve, reduce how often the drops are given, and do it gradually. Take care not to stop the treatment too early.
Side Effects
Dexamethasone + Chloramphenicol can cause the reactions seen with Chloramphenicol, which are burning or discomfort in the eye that passes quickly. Other reactions reported include stinging, redness, itching, conjunctivitis, foreign body sensation, photophobia, blurred vision, dryness and eye pain. Allergic sensitization may occur with local use of Chloramphenicol. The pressure inside the eye (intraocular pressure) may rise, and glaucoma may possibly develop. Optic nerve damage is infrequent, and posterior subcapsular cataract formation may also be seen.
Cautions & Contraindications
Warnings & Precautions
After prolonged use of a corticosteroid like the one in Dexamethasone + Chloramphenicol, a fungal infection of the cornea that doesn't clear up should be kept in mind. Using steroid-containing products for a long time may also cause posterior subcapsular cataract, and glaucoma with damage to the optic nerve, so intraocular pressure needs to be monitored. Long use of an antibiotic can let organisms that aren't susceptible to it overgrow, fungi included. If a new infection appears during treatment, stop the medicine and start alternative therapy.
Contraindications
Dexamethasone with Chloramphenicol must not be used in epithelial herpes simplex cornealis, or in fungal, viral, tuberculous and other infections of the eye. It is also contraindicated in glaucoma. Don't give it to anyone who developed myelosuppression during earlier exposure to Chloramphenicol, or to anyone with hypersensitivity to Chloramphenicol, Dexamethasone Phosphate or any other ingredient in the preparations.
Pregnancy & Breastfeeding
No adequate and well-controlled studies have been done in pregnant women. So Dexamethasone + Chloramphenicol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Take caution when Chloramphenicol and Dexamethasone ophthalmic solution is given to a nursing mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Dexamethasone + Chloramphenicol in a cool, dry place away from light, and keep it out of the reach of children. Don't use it after 30 days from the day you first open it.
Drug Interactions
Common questions about Cloradex 0.1%+0.5%
What is Cloradex 0.1%+0.5% Ophthalmic Solution?
Cloradex 0.1%+0.5% Ophthalmic Solution is a medicine that contains Dexamethasone + Chloramphenicol. It is made by Navana Pharmaceuticals Ltd. It belongs to the Anti-infectives & antiseptics group of medicines.
What is Cloradex used for?
Cloradex is used for: Bacterial Infection, Otitis Media, Conjunctivitis, Inflammation.
What are the side effects of Cloradex?
Dexamethasone + Chloramphenicol can cause the reactions seen with Chloramphenicol, which are burning or discomfort in the eye that passes quickly. Other reactions reported include stinging, redness, itching, conjunctivitis, foreign body sensation, photophobia, blurred vision, dryness and eye pain.
Can I take Cloradex during pregnancy or while breastfeeding?
No adequate and well-controlled studies have been done in pregnant women. So Dexamethasone + Chloramphenicol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cloradex?
Store Dexamethasone + Chloramphenicol in a cool, dry place away from light, and keep it out of the reach of children. Don't use it after 30 days from the day you first open it.
Can I take other medicines with Cloradex?
Some medicines can interact with Dexamethasone + Chloramphenicol, for example: Chloramphenicol, Rifampicin, Dexamethasone, Phenobarbitone, Phenytoin, Phenobarbital. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cloradex?
Cloradex is a prescription (Rx) medicine. Take it as your doctor advises.