Indications
Desoximetasone cream is used to relieve the inflammation and itching that come with skin conditions that respond to corticosteroids.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Nobody knows exactly how topical steroids like desoximetasone reduce inflammation in steroid-responsive skin conditions. The usual explanation is that corticosteroids work by inducing proteins that inhibit phospholipase A2, which are together called lipocortins. First the drug binds to glucocorticoid receptors. The receptor then moves into the nucleus and binds to DNA, which switches various genes on and off.
These proteins are thought to control the making of strong inflammatory mediators such as prostaglandins and leukotrienes. They do this by blocking the release of arachidonic acid, the common precursor of both. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pregnancy & Breastfeeding
No well-controlled studies of Desoximetasone have been done in pregnant women. So it should be used during pregnancy only if the likely benefit is greater than the possible risk to the baby. It isn't known whether Desoximetasone applied to the skin is absorbed into the body enough to appear in breast milk in a measurable amount. Even so, a nursing mother should use topical corticosteroids with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.