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Indications & Uses
Minirin Melt is indicated for:
Pharmacology
Desmopressin copies the action of the body's own ADH. It acts as a selective agonist at the V2 receptors in the renal collecting duct (CD), so the kidneys take back more water and make less urine. In patients with hemophilia and von Willebrand's disease Type I, desmopressin has been shown to raise plasma levels of factor VIII activity more than ADH does. Its pressor activity is markedly diminished. Given intranasally, desmopressin has an antidiuretic effect of about one-tenth that of an equivalent dose given by injection. Upon binding to the V2 receptors in the basolateral membrane of the cells of the distal tubule and collecting ducts of the nephron, adenylyl cyclase is stimulated. The intracellular cascades that follow in the collecting duct increase the rate at which water channels, called aquaporins, are inserted into the lumenal membrane, and the membrane becomes more permeable to water.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Desmopressin Acetate sublingual tablet is used for the treatment of diabetes insipidus. The dose is individual in this condition, but the total daily sublingual dose normally lies between 120 micrograms and 720 micrograms. A suitable starting dose in adults and children is 60 micrograms three times daily, taken sublingually. The doctor then adjusts this according to how the patient responds. For most patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily. In post-hypophysectomy polyuria/polydipsia, the dose of Desmopressin Acetate Melt should be controlled by measuring urine osmolality.
For the film coated tablet in adults and children, patients should be started on 0.05 mg (1/2 of the 0.1 mg tablet) two times a day. The dose is then adjusted for each person until the best therapeutic dose is reached. Most patients in clinical trials found the best dosage range was 0.1 mg to 0.8 mg daily, given in divided doses. Each dose should be adjusted separately so that the body's water turnover keeps an adequate diurnal rhythm. The total daily dosage should be increased or decreased within the range of 0.1 mg to 1.2 mg, divided into two or three daily doses, as needed to get adequate antidiuresis.
For geriatric use, this medicine is known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Elderly patients are more likely to have decreased renal function, so care should be taken in choosing the dose, and it may be useful to monitor renal function.
Side Effects
Large doses of the intranasal formulations of Desmopressin Acetate Tablets and Desmopressin Acetate Injection have infrequently caused a short-lived headache, nausea, flushing and mild abdominal cramps. These symptoms went away when the dose was reduced.
Cautions & Contraindications
Warnings & Precautions
Very rare cases of hyponatremia have been reported from worldwide postmarketing experience in patients treated with Desmopressin Acetate Tablets. The medicine is a potent antidiuretic, so it may lead to water intoxication and hyponatremia. Unless hyponatremia is properly diagnosed and treated, it can be fatal. For this reason, fluid restriction is recommended and should be discussed with the patient and/or guardian. Careful medical supervision is required. Desmopressin Acetate at high doses in intranasal formulations, and Desmopressin Acetate Injection, have infrequently produced a slight rise in blood pressure, which disappears when the dose is reduced. This effect has not been seen with single oral doses up to 0.6 mg. Even so, the medicine should be used with caution in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease, because their blood pressure may rise.
Contraindications
Don't give Desmopressin Acetate Tablets to anyone who is known to be allergic to desmopressin acetate or to any other ingredient in the tablets. They are also not for patients with moderate to severe kidney problems, meaning a creatinine clearance below 50 mL/min. And patients with hyponatremia, or a past history of it, should not take them either.
Pregnancy & Breastfeeding
No controlled studies have been done in nursing mothers, so doctors should take care when giving desmopressin acetate to a woman who is breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Desmopressin Acetate in a dry place, at a temperature not above 30°C. Protect it from light and moisture.
Drug Interactions
Common questions about Minirin Melt 120 mcg
What is Minirin Melt 120 mcg Sublingual Tablet?
Minirin Melt 120 mcg Sublingual Tablet is a medicine that contains Desmopressin Acetate. It is made by Radiant Pharmaceuticals Ltd. It belongs to the Synthetic analogue of ADH group of medicines.
What is Minirin Melt used for?
Minirin Melt is used for: Diabetes Mellitus.
What are the side effects of Minirin Melt?
Large doses of the intranasal formulations of Desmopressin Acetate Tablets and Desmopressin Acetate Injection have infrequently caused a short-lived headache, nausea, flushing and mild abdominal cramps. These symptoms went away when the dose was reduced.
Can I take Minirin Melt during pregnancy or while breastfeeding?
No controlled studies have been done in nursing mothers, so doctors should take care when giving desmopressin acetate to a woman who is breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Minirin Melt?
Keep Desmopressin Acetate in a dry place, at a temperature not above 30°C. Protect it from light and moisture.
Can I take other medicines with Minirin Melt?
Some medicines can interact with Desmopressin Acetate, for example: Lamotrigine, Carbamazepine, Ticagrelor, Chlorpromazine Hydrochloride, Loperamide + Simethicone. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Minirin Melt is already among the lowest-priced brands of Desmopressin Acetate at this strength.
Do I need a prescription for Minirin Melt?
Minirin Melt is a prescription (Rx) medicine. Take it as your doctor advises.