Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Parkinson's Disease Schizophrenia

Sensipin is used to treat schizophrenia in patients who have not responded well to, or cannot tolerate, standard antipsychotic medicines. It is also used for psychosis occurring in Parkinson's disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clozapine is classified as an "atypical" antipsychotic because its profile of binding to dopamine receptors, and its effects on various dopamine-mediated behaviors, differ from those seen with other typical antipsychotic drugs. Clozapine does interfere with the binding of dopamine at the D1, D2, D3 and D5 receptors, and it has a high affinity for the D4 receptor. This evidence supports the view that Clozapine is preferentially more active at limbic than at striatal dopamine receptors, which may explain its relative freedom from extrapyramidal side effects. Clozapine also acts as an antagonist at adrenergic, cholinergic, histaminergic and serotonergic receptors.

Pregnancy & Breastfeeding

Clozapine hasn't been studied thoroughly in pregnant women, though animal studies haven't pointed to any significant risk to the developing baby. If a doctor judges it necessary, it can still be used during pregnancy. As for breastfeeding, animal research shows Clozapine passes into breast milk, so mothers taking this medicine should avoid nursing their infants.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Schizophrenia: Adult over 16 years, 12.5 mg once or twice (elderly 12.5 mg once) on first day then 25-50 mg (elderly 25-37.5 mg) on second day then increased gradually (if well tolerated) in steps of 25-50 mg daily (elderly max. increment 25 mg daily) over 14-21 days up to 300 mg daily in divided doses (larger dose at night, up to 200 mg daily may be taken as a single dose at bedtime); if necessary may be further increased in steps of 50-100 mg once (preferably) or twice weekly; usual dose 200-450 mg daily (max. 900 mg daily)Psychosis in Parkinson's disease: Adult over 16 years, 12.5 mg at bedtime then increased according to response in steps of 12.5 mg up to twice weekly; usual dose range 25-37.5 mg at bedtime, usual maximum 50 mg daily; exceptionally, dose may be increased further in steps of 12.5 mg weekly to maximum 100 mg daily in 1-2 divided doses.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.