Indications
For acute coronary syndrome (ACS), Clopidogrel Bisulphate tablet is used to reduce the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)]. It is also used to reduce the rate of myocardial infarction and stroke in patients with acute ST-elevation myocardial infarction (STEMI). Patients with established peripheral arterial disease, or with a history of recent MI or recent stroke, take the tablet for the same purpose, which is to reduce the rate of MI and stroke.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Clopidogrel is a prodrug, so the body has to convert it before it works. Its active metabolite binds irreversibly to the P2Y12 class of ADP receptors on platelets, and this stops platelets from being activated and clumping together. After single oral doses, dose-dependent inhibition of platelet aggregation can be seen at 2 hours. With repeated doses of 75 mg per day, clopidogrel inhibits ADP-induced platelet aggregation from the first day, and the inhibition reaches steady state between Day 3 and Day 7.
Pregnancy & Breastfeeding
No adequate and well-controlled studies have been done in pregnant women, so clopidogrel should be used during pregnancy only if it is clearly needed. It is not known whether clopidogrel passes into human breast milk. A decision has to be made either to stop breastfeeding or to stop the medicine, and that decision should take into account how important the medicine is for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.