Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Clomipramine Hydrochloride is used to treat Obsessive Compulsive Disorder (OCD), Major Depressive Disorder (MDD) and depression.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clomipramine Hydrochloride is an original tricyclic antidepressant and belongs to the dibenzazepine group of compounds. It is presumed to act on obsessive and compulsive behaviours through its effects on serotonergic neuronal transmission. The exact neurochemical mechanism isn't known. But the medicine can inhibit the reuptake of serotonin (5-HT), and this is thought to be important (as with obsessions and compulsions), which in turn hampers social acquaintance.

Pregnancy & Breastfeeding

There are no adequate, well-controlled studies on the safety of clomipramine in pregnancy. Limited data suggest that clomipramine is likely to pass into human breast milk. It also has a known risk of damage to the fetus.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The initial dose of Clomipramine Hydrochloride is 25 mg at bedtime for about a week. After that the dose is raised gradually, but it should not go above 150 mg per day in adults and 75 mg per day in elderly patients. The dose can be given in divided form to reduce gastrointestinal disturbances. Clomipramine is not recommended for children.

Side Effects & Interactions